Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model

Simon D. Baines; Rachel O'Connor; Katie Saxton; Jane Freeman; M. H. Wilcox

doi:10.1093/jac/dkn502

Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model

Simon D. Baines, Rachel O'Connor, Katie Saxton, Jane Freeman, M. H. Wilcox

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Vancomycin and metronidazole remain the only primary options for the treatment of Clostridium difficile infection (CDI). Recent reports have suggested a superior clinical response to vancomycin therapy compared with metronidazole, but this has been difficult to prove or explain. There are few robust in vitro data of the effects of antibiotic treatment of CDI in a gut reflective setting.

Original language	English
Pages (from-to)	520-5
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	63
Issue number	3
DOIs	https://doi.org/10.1093/jac/dkn502
Publication status	Published - 2009

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title = "Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model",

abstract = "Vancomycin and metronidazole remain the only primary options for the treatment of Clostridium difficile infection (CDI). Recent reports have suggested a superior clinical response to vancomycin therapy compared with metronidazole, but this has been difficult to prove or explain. There are few robust in vitro data of the effects of antibiotic treatment of CDI in a gut reflective setting.",

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AB - Vancomycin and metronidazole remain the only primary options for the treatment of Clostridium difficile infection (CDI). Recent reports have suggested a superior clinical response to vancomycin therapy compared with metronidazole, but this has been difficult to prove or explain. There are few robust in vitro data of the effects of antibiotic treatment of CDI in a gut reflective setting.

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

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Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model

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