Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model

Simon D. Baines, Rachel O'Connor, Katie Saxton, Jane Freeman, M. H. Wilcox

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Vancomycin and metronidazole remain the only primary options for the treatment of Clostridium difficile infection (CDI). Recent reports have suggested a superior clinical response to vancomycin therapy compared with metronidazole, but this has been difficult to prove or explain. There are few robust in vitro data of the effects of antibiotic treatment of CDI in a gut reflective setting.
Original languageEnglish
Pages (from-to)520-5
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume63
Issue number3
DOIs
Publication statusPublished - 2009

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