Advances in oral transmucosal drug delivery

Viralkumar F. Patel, Fang Liu, Marc Brown

Research output: Contribution to journalLiterature reviewpeer-review

313 Citations (Scopus)
3726 Downloads (Pure)

Abstract

The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. This review highlights the physiological challenges as well as the advances and opportunities for buccal/sublingual drug delivery. Particular attention is given to new approaches which can extend dosage form retention time or can be engineered to deliver complex molecules such as proteins and peptides. The review will also discuss the physiology and local environment of the oral cavity in vivo and how this relates to the performance of transmucosal delivery systems.
Original languageEnglish
Pages (from-to)106-116
Number of pages11
JournalJournal of Controlled Release
Volume153
Issue number2
DOIs
Publication statusPublished - 30 Jul 2011

Keywords

  • Transmucosal
  • Permeation pathways
  • Buccal absorption
  • Mucoadhesive
  • Dosage forms
  • PORCINE BUCCAL MUCOSA
  • IN-VITRO EVALUATION
  • CARRIER-MEDIATED TRANSPORT
  • MEMBRANE-COATING GRANULES
  • CELL-CULTURE MODEL
  • MUCOADHESIVE POLYMERS
  • TRANSBUCCAL DELIVERY
  • GASTROINTESTINAL-TRACT

Fingerprint

Dive into the research topics of 'Advances in oral transmucosal drug delivery'. Together they form a unique fingerprint.

Cite this