AI-Guided GDMT Optimization After HFrEF Hospitalization The ASSIST-HF SIRIO Randomized Pilot Trial

Eliano P. Navarese; Joshua H. Leader; Rafaella I.L. Markides; Sogol Koolaji; Dean J. Kereiakes; Jacek Kubica; Mehriban Isgender; Thomas F. Lüscher; Diana A. Gorog

doi:10.1016/j.jacc.2025.12.066

AI-Guided GDMT Optimization After HFrEF Hospitalization The ASSIST-HF SIRIO Randomized Pilot Trial

Eliano P. Navarese
, Joshua H. Leader
, Rafaella I.L. Markides
, Sogol Koolaji
, Dean J. Kereiakes
, Jacek Kubica
, Mehriban Isgender
, Thomas F. Lüscher
, Diana A. Gorog

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Journal of the American College of Cardiology
Early online date	11 Feb 2026
DOIs	https://doi.org/10.1016/j.jacc.2025.12.066
Publication status	E-pub ahead of print - 11 Feb 2026

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Cite this

@article{615e82b2c2884686aba9ac99acf0d47d,

title = "AI-Guided GDMT Optimization After HFrEF Hospitalization The ASSIST-HF SIRIO Randomized Pilot Trial",

author = "Navarese, \{Eliano P.\} and Leader, \{Joshua H.\} and Markides, \{Rafaella I.L.\} and Sogol Koolaji and Kereiakes, \{Dean J.\} and Jacek Kubica and Mehriban Isgender and L{\"u}scher, \{Thomas F.\} and Gorog, \{Diana A.\}",

note = "{\textcopyright} 2026, American College of Cardiology Foundation. Published by Elsevier.",

year = "2026",

month = feb,

day = "11",

doi = "10.1016/j.jacc.2025.12.066",

language = "English",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier",

}

TY - JOUR

T1 - AI-Guided GDMT Optimization After HFrEF Hospitalization The ASSIST-HF SIRIO Randomized Pilot Trial

AU - Navarese, Eliano P.

AU - Leader, Joshua H.

AU - Markides, Rafaella I.L.

AU - Koolaji, Sogol

AU - Kereiakes, Dean J.

AU - Kubica, Jacek

AU - Isgender, Mehriban

AU - Lüscher, Thomas F.

AU - Gorog, Diana A.

PY - 2026/2/11

Y1 - 2026/2/11

U2 - 10.1016/j.jacc.2025.12.066

DO - 10.1016/j.jacc.2025.12.066

M3 - Article

SN - 0735-1097

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

ER -