An intraoperative visualization system using hyperspectral imaging to aid in brain tumor delineation

Himar Fabelo, Samuel Ortega, Raquel Lazcano, Daniel Madroñal, Gustavo M. Callicó, Eduardo Juárez, Rubén Salvador, Diederik Bulters, Harry Bulstrode, Adam Szolna, Juan F. Piñeiro, Coralia Sosa, Aruma J. O’Shanahan, Sara Bisshopp, María Hernández, Jesús Morera, Daniele Ravi, B. Ravi Kiran, Aurelio Vega, Abelardo Báez-QuevedoGuang Zhong Yang, Bogdan Stanciulescu, Roberto Sarmiento

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Hyperspectral imaging (HSI) allows for the acquisition of large numbers of spectral bands throughout the electromagnetic spectrum (within and beyond the visual range) with respect to the surface of scenes captured by sensors. Using this information and a set of complex classification algorithms, it is possible to determine which material or substance is located in each pixel. The work presented in this paper aims to exploit the characteristics of HSI to develop a demonstrator capable of delineating tumor tissue from brain tissue during neurosurgical operations. Improved delineation of tumor boundaries is expected to improve the results of surgery. The developed demonstrator is composed of two hyperspectral cameras covering a spectral range of 400-1700 nm. Furthermore, a hardware accelerator connected to a control unit is used to speed up the hyperspectral brain cancer detection algorithm to achieve processing during the time of surgery. A labeled dataset comprised of more than 300,000 spectral signatures is used as the training dataset for the supervised stage of the classification algorithm. In this preliminary study, thematic maps obtained from a validation database of seven hyperspectral images of in vivo brain tissue captured and processed during neurosurgical operations demonstrate that the system is able to discriminate between normal and tumor tissue in the brain. The results can be provided during the surgical procedure (~1 min), making it a practical system for neurosurgeons to use in the near future to improve excision and potentially improve patient outcomes.

Original languageEnglish
Article number430
Issue number2
Publication statusPublished - 1 Feb 2018


  • Brain cancer detection
  • Hyperspectral imaging instrumentation
  • Image processing


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