Analysis and design optimization of an integrated micropump-micromixer operated for bio-MEMS applications

Cesar Cortes, Alireza Azarbadegan, Ian Johnston, M.C. Tracey

Research output: Contribution to conferencePaperpeer-review

293 Downloads (Pure)


A generic microfluidic system composed by two single chamber valveless micropumps connected to a simple T-type channel intersection is examined numerically. The characteristics of a feasible valveless micropump have been used in the design, where efficient mixing is produced due to the pulsating flow generated by the micropumps. The advantages of using time pulsing inlet flows for enhancing mixing in channels have been harnessed through the activation of intrinsic characteristics of the pumps required to achieve the periodic flows.
A parametric study is carried out on this microfluidic system using Computational Fluids Dynamics (CFD) on a design space defined by a Design-of-Experiments (DOE) technique. With this approach, the frequency f and the phase difference  of the periodic fluid velocities (operation parameters) and the angle  formed by the inlet channels at the intersection (geometric parameter) are used as design parameters, whereas mixing quality, pressure drop and maximum shear strain rate in the channel are the performance parameters. The study identifies design features for which the pressure drop and shear strain in the channel are reduced whereas the mixing quality is increased.
The proposed microfluidic system achieves high mixing quality with performance parameters that enable manipulation of biological fluids in microchannels.
Original languageEnglish
Publication statusPublished - 7 Sept 2014
Event4th Micro and Nano Flows Conference (MNF 2014) - University College London, Roberts building (Engineering), London, United Kingdom
Duration: 7 Sept 201410 Sept 2014


Conference4th Micro and Nano Flows Conference (MNF 2014)
Country/TerritoryUnited Kingdom


  • Microfluidics, Micropump-micromixer, Parallel Valveless Micropump, Pulsating Flow, Microsystem Design, Optimization


Dive into the research topics of 'Analysis and design optimization of an integrated micropump-micromixer operated for bio-MEMS applications'. Together they form a unique fingerprint.

Cite this