Anosognosia for hemiplegia as a tripartite disconnection syndrome

Valentina Pacella; Chris Foulon; Paul M Jenkinson; Michele Scandola; Sara Bertagnoli; Renato Avesani; Aikaterini Fotopoulou; Valentina Moro; Michel Thiebaut de Schotten

doi:10.7554/eLife.46075

Anosognosia for hemiplegia as a tripartite disconnection syndrome

Valentina Pacella, Chris Foulon, Paul M Jenkinson, Michele Scandola, Sara Bertagnoli, Renato Avesani, Aikaterini Fotopoulou, Valentina Moro, Michel Thiebaut de Schotten

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Abstract

The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.

Original language	English
Article number	e46075
Number of pages	13
Journal	eLife
Volume	8
DOIs	https://doi.org/10.7554/eLife.46075
Publication status	Published - 6 Aug 2019

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10.7554/eLife.46075Licence: CC BY

Pacella et al - 2019 - Anosognosia for hemiplegia as a tripartite disconnection syndrome
© 2019 Pacella et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Final published version, 5.29 MBLicence: CC BY

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abstract = "The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.",

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AU - Bertagnoli, Sara

AU - Avesani, Renato

AU - Fotopoulou, Aikaterini

AU - Moro, Valentina

AU - Thiebaut de Schotten, Michel

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Anosognosia for hemiplegia as a tripartite disconnection syndrome

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