Anosognosia for hemiplegia as a tripartite disconnection syndrome

Valentina Pacella, Chris Foulon, Paul M Jenkinson, Michele Scandola, Sara Bertagnoli, Renato Avesani, Aikaterini Fotopoulou, Valentina Moro, Michel Thiebaut de Schotten

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
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The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.
Original languageEnglish
Article numbere46075
Number of pages13
Publication statusPublished - 6 Aug 2019


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