Antibiotic Stewardship in Sepsis Management

This presentation highlights key principles of antibiotic stewardship in sepsis management to optimise patient outcomes and reduce antimicrobial resistance. Emphasis is placed on obtaining routine microbiologic cultures before initiating antimicrobials, provided no substantial delay occurs. It underscores the importance of prompt intervention for infections requiring source control and immediate administration of IV antimicrobials within one hour of recognising sepsis or septic shock. Treatment should include at least one active agent with optimised dosing based on pharmacokinetics/pharmacodynamics. Daily assessments for de-escalation are vital, avoiding prophylaxis in noninfectious inflammatory states. Effective stewardship can reduce mortality risks and ensure appropriate antimicrobial use in sepsis.