TY - JOUR
T1 - Are low erythropoietin and 1,25-dihydroxyvitamin D levels indicative of tubulo-interstitial dysfunction in diabetes without persistent microalbuminuria?
AU - Singh, D.K.
AU - Winocour, P.
AU - Summerhayes, B.
AU - Viljoen, A.
AU - Sivakumar, G.
AU - Farrington, Ken
N1 - Original article can be found at : http://www.sciencedirect.com/ Copyright Elsevier [Full text of this article is not available in the UHRA]
PY - 2009
Y1 - 2009
N2 - Aims: To investigate the relationship between Erythropoietin (EPO) and 1,25-dihydroxyvitamin D levels, and tubular damage in patients with diabetes mellitus (DM) without persistent microalbuminuria. Methods: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-β-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM. Results: Median serum EPO levels were lower in Type 1 (2.57 mIU/ml: p < 0.001) and Type 2 DM (5.69 mIU/ml: p = 0.044) than in controls (8.76 mIU/ml), though haemoglobin levels did not differ. Median 1,25-dihydroxyvitamin D levels were lower in Type 1 (41.0 pmol/l: p = 0.001) and Type 2 DM (41.8 pmol/l: p = 0.035) than in controls (56.1 pmol/l), though serum creatinine, calcium, phosphate and PTH levels did not differ. Median RBP excretion was higher in Type 2 DM (0.35 mg/l vs. 0.23 mg/l: p = 0.013) than in controls. Median NAG excretion was higher in Type 1 DM (1079 μmol/h vs.1030 μmol/h: p = 0.048) compared to controls. Conclusions: Tubulo-interstitial damage with low levels of EPO and 1,25-dihydroxyvitamin D occurs early in Type 1 and Type 2 DM before persistent microalbuminuria.
AB - Aims: To investigate the relationship between Erythropoietin (EPO) and 1,25-dihydroxyvitamin D levels, and tubular damage in patients with diabetes mellitus (DM) without persistent microalbuminuria. Methods: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-β-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM. Results: Median serum EPO levels were lower in Type 1 (2.57 mIU/ml: p < 0.001) and Type 2 DM (5.69 mIU/ml: p = 0.044) than in controls (8.76 mIU/ml), though haemoglobin levels did not differ. Median 1,25-dihydroxyvitamin D levels were lower in Type 1 (41.0 pmol/l: p = 0.001) and Type 2 DM (41.8 pmol/l: p = 0.035) than in controls (56.1 pmol/l), though serum creatinine, calcium, phosphate and PTH levels did not differ. Median RBP excretion was higher in Type 2 DM (0.35 mg/l vs. 0.23 mg/l: p = 0.013) than in controls. Median NAG excretion was higher in Type 1 DM (1079 μmol/h vs.1030 μmol/h: p = 0.048) compared to controls. Conclusions: Tubulo-interstitial damage with low levels of EPO and 1,25-dihydroxyvitamin D occurs early in Type 1 and Type 2 DM before persistent microalbuminuria.
KW - tubulo-interstitium
KW - erythropoietin
KW - 1,25-dihydroxyvitamin D
KW - N-acetyl-β-d-glucosaminidase
KW - Retinol binding protein
UR - http://www.scopus.com/inward/record.url?scp=68249102138&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2009.06.022
DO - 10.1016/j.diabres.2009.06.022
M3 - Article
SN - 0168-8227
VL - 85
SP - 258
EP - 264
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 3
ER -