Assessment of changes in tumor heterogeneity following neoadjuvant chemotherapy in primary esophageal cancer

C. Yip, F. Davnall, R. Kozarski, D. B. Landau, G. J R Cook, P. Ross, R. Mason, V. Goh

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57 Citations (Scopus)


To assess the changes in computed tomography (CT) tumor heterogeneity following neoadjuvant chemotherapy in esophageal cancer. Thirty-one consecutive patients who received neoadjuvant chemotherapy for esophageal cancer were identified. Analysis of primary tumor heterogeneity (texture) was performed on staging and post-chemotherapy CT scans. Image texture parameters (mean grey-level intensity, entropy, uniformity, kurtosis, skewness, standard deviation of histogram) were derived for different levels of image filtration (0-2.5). Proportional changes in each parameter following treatment were obtained. Comparison between pathological tumor response and texture parameters was analyzed using Mann-Whitney U-test. The relationship between CT texture and overall survival) was estimated using the Kaplan-Meier method. Tumor texture became more homogeneous after treatment with a significant decrease in entropy and increase in uniformity (filter 1.0 and 2.5). Pretreatment (filter 1.5, P = 0.006) and posttreatment standard deviation of histogram (filter 1.0, P = 0.009) showed a borderline association with pathological tumor response. A proportional change in skewness <0.39 (filter 1.0) was associated with improved survival (median overall survival 36.1 vs. 11.1 months; P < 0.001). CT tumor heterogeneity decreased following neoadjuvant chemotherapy and has the potential to provide additional information in primary esophageal cancer.

Original languageEnglish
Pages (from-to)172-179
JournalDiseases of the Esophagus
Issue number2
Early online date29 Jan 2014
Publication statusPublished - Feb 2015


  • CT
  • Esophageal cancer
  • Neoadjuvant chemotherapy
  • Prognosis
  • Texture analysis


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