Benefits and Harms of 'Smart Drugs' (Nootropics) in Healthy Individuals

Fabrizio Schifano, Valeria Catalani, Safia (Sophia) Sharif, Flavia Napoletano, John Corkery, Davide Arillotta, Suzanne Fergus, Alessandro Vento, Amira Guirguis

Research output: Contribution to journalReview articlepeer-review

732 Downloads (Pure)


‘Smart drugs’ (also known as ‘nootropics’ and ‘cognitive enhancers’ [CEs]) are being used by healthy subjects (i.e. students and workers) typically to improve memory, attention, learning, executive functions and vigilance, hence the reference to a ‘pharmaceutical cognitive doping behaviour’. While the efficacy of known CEs in individuals with memory or learning deficits is well known, their effect on non-impaired brains is still to be fully assessed. This paper aims to provide an overview on the prevalence of use; putative neuroenhancement benefits and possible harms relating to the intake of the most popular CEs (e.g. amphetamine-type stimulants, methylphenidate, donepezil, selegiline, modafinil, piracetam, benzodiazepine inverse agonists, and unifiram analogues) in healthy individuals. CEs are generally perceived by the users as effective, with related enthusiastic anecdotal reports; however, their efficacy in healthy individuals is uncertain and any reported improvement temporary. Conversely, since most CEs are stimulants, the related modulation of central noradrenaline, glutamate, and dopamine levels may lead to cardiovascular, neurological and psychopathological complications. Furthermore, use of CEs can be associated with paradoxical short- and long-term cognitive decline; decreased potential for plastic learning; and addictive behaviour. Finally, the non-medical use of any potent psychotropic raises serious ethical and legal issues, with nootropics having the potential to become a major public health concern. Further studies investigating CE-associated social, psychological, and biological outcomes are urgently needed to allow firm conclusions to be drawn on the appropriateness of CE use in healthy individuals.
Original languageEnglish
Article numberDRUA-D-21-00333R1
Pages (from-to)633-647
Number of pages15
Issue number6
Early online date2 Apr 2022
Publication statusPublished - 2 Apr 2022


  • nootropics
  • benefits
  • harms
  • 'smart drugs'


Dive into the research topics of 'Benefits and Harms of 'Smart Drugs' (Nootropics) in Healthy Individuals'. Together they form a unique fingerprint.

Cite this