TY - JOUR
T1 - Beyond symptom dimensions
T2 - schizophrenia risk factors for patient groups derived by latent class analysis
AU - Leask, S.K.
AU - Vermunt, J.K.
AU - Done, D.J.
AU - Crow, T.J.
AU - Blows, M.
AU - Bloks, M.P.
N1 - Original article can be found at : http://www.sciencedirect.com/ Copyright Elsevier [Full text of this article is not available in the UHRA]
PY - 2009
Y1 - 2009
N2 - Introduction : Patients grouped by latent class analysis of symptoms show some consensus between studies, and may be less etiologically heterogeneous than current diagnoses. If so, the effect size of ‘neurodevelopmental’ risk factors may be greater than in equivalent DSMIV diagnostic groups. Method : Two hundred fifty six individuals with neurodevelopmental risk factors recorded in the National Child Development Study (1958) UK birth cohort were grouped by data-driven illness subtypes, derived previously in over 1000 individuals. The effect sizes of these risks were compared between data-derived and DSMIV schizophrenia (295.x) groups. Results : Compared to DSMIV schizophrenia, the data-driven subtype broadly characterized by the presence of psychotic symptoms in the absence of affective symptoms showed significantly greater effect sizes in eight out of thirteen continuously-rated risk factors: birth weight, cognition, childhood behavioural problems, and neurological softsigns including handedness. Conclusion : A data-driven subgroup of schizophrenia patients, characterized as lacking co-morbid depressive symptoms, is less heterogeneous with respect to neurodevelopmental etiology.
AB - Introduction : Patients grouped by latent class analysis of symptoms show some consensus between studies, and may be less etiologically heterogeneous than current diagnoses. If so, the effect size of ‘neurodevelopmental’ risk factors may be greater than in equivalent DSMIV diagnostic groups. Method : Two hundred fifty six individuals with neurodevelopmental risk factors recorded in the National Child Development Study (1958) UK birth cohort were grouped by data-driven illness subtypes, derived previously in over 1000 individuals. The effect sizes of these risks were compared between data-derived and DSMIV schizophrenia (295.x) groups. Results : Compared to DSMIV schizophrenia, the data-driven subtype broadly characterized by the presence of psychotic symptoms in the absence of affective symptoms showed significantly greater effect sizes in eight out of thirteen continuously-rated risk factors: birth weight, cognition, childhood behavioural problems, and neurological softsigns including handedness. Conclusion : A data-driven subgroup of schizophrenia patients, characterized as lacking co-morbid depressive symptoms, is less heterogeneous with respect to neurodevelopmental etiology.
KW - symptom dimensions
KW - risk factors
KW - psychosis
KW - genetics
KW - neurodevelopment
U2 - 10.1016/j.schres.2009.09.017
DO - 10.1016/j.schres.2009.09.017
M3 - Article
SN - 0920-9964
VL - 115
SP - 346
EP - 350
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2-3
ER -