Bioluminescence-based measurement of viability of Pseudomonas aeruginosa ATCC 9027 harbouring plasmid-based lux genes under the control of constitutive promoters

Niksha Shah, David Naseby

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
19 Downloads (Pure)

Abstract

Detection of microbial contamination in pharmaceuticals, food and cosmetics has been problematic for several decades. Numerous investigations highlight the urgency for novel methods; development of bioluminescent constructs allows real-time monitoring, rapid analysis and high-throughput screening of products. Microbial growth can be studied by measuring constitutive gene expression. The aim is to develop whole-cell microbial biosensors with Pseudomonas aeruginosa and quantify their growth rate by measuring constitutive expression of lux
Original languageEnglish
Pages (from-to)1373-1387
JournalJournal of Applied Microbiology
Volume117
Issue number5
Early online date3 Oct 2014
DOIs
Publication statusPublished - Nov 2014

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