Bioprosthetic valve thrombosis and degeneration following transcatheter aortic valve implantation (TAVI)

Saeed Mirsadraee; Diana Gorog

doi:10.1016/j.crad.2020.08.015

Bioprosthetic valve thrombosis and degeneration following transcatheter aortic valve implantation (TAVI)

Saeed Mirsadraee, Diana Gorog

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Abstract

Bioprosthetic valve thrombosis (BPVT) is a recognised complication of prosthetic aortic valves and can be seen in up to 13% of patients after transcatheter implantation.The mechanism of BPVT is not well known, abnormal flow conditions in the new and native sinuses and lack of functional endothelialisation are suspected causes. BPVT may result in valve dysfunction, possibly related to degeneration, and recurrence of patient symptoms, or remain subclinical. BPVT is best diagnosed by multiphase gated CT angiography as the presence of reduced leaflet motion (RELM) and hypoattenuating aortic leaflet thickening (HALT). Whilst CT is used to exclude BPVT in symptomatic patients and those with increased valve gradient, the value of screening and prophylactic anticoagulation is debatable.

Original language	English
Journal	Clinical Radiology
Early online date	9 Sept 2020
DOIs	https://doi.org/10.1016/j.crad.2020.08.015
Publication status	E-pub ahead of print - 9 Sept 2020

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© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/.
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title = "Bioprosthetic valve thrombosis and degeneration following transcatheter aortic valve implantation (TAVI)",

abstract = "Bioprosthetic valve thrombosis (BPVT) is a recognised complication of prosthetic aortic valves and can be seen in up to 13% of patients after transcatheter implantation.The mechanism of BPVT is not well known, abnormal flow conditions in the new and native sinuses and lack of functional endothelialisation are suspected causes. BPVT may result in valve dysfunction, possibly related to degeneration, and recurrence of patient symptoms, or remain subclinical. BPVT is best diagnosed by multiphase gated CT angiography as the presence of reduced leaflet motion (RELM) and hypoattenuating aortic leaflet thickening (HALT). Whilst CT is used to exclude BPVT in symptomatic patients and those with increased valve gradient, the value of screening and prophylactic anticoagulation is debatable. ",

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AU - Mirsadraee, Saeed

AU - Gorog, Diana

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PY - 2020/9/9

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N2 - Bioprosthetic valve thrombosis (BPVT) is a recognised complication of prosthetic aortic valves and can be seen in up to 13% of patients after transcatheter implantation.The mechanism of BPVT is not well known, abnormal flow conditions in the new and native sinuses and lack of functional endothelialisation are suspected causes. BPVT may result in valve dysfunction, possibly related to degeneration, and recurrence of patient symptoms, or remain subclinical. BPVT is best diagnosed by multiphase gated CT angiography as the presence of reduced leaflet motion (RELM) and hypoattenuating aortic leaflet thickening (HALT). Whilst CT is used to exclude BPVT in symptomatic patients and those with increased valve gradient, the value of screening and prophylactic anticoagulation is debatable.

AB - Bioprosthetic valve thrombosis (BPVT) is a recognised complication of prosthetic aortic valves and can be seen in up to 13% of patients after transcatheter implantation.The mechanism of BPVT is not well known, abnormal flow conditions in the new and native sinuses and lack of functional endothelialisation are suspected causes. BPVT may result in valve dysfunction, possibly related to degeneration, and recurrence of patient symptoms, or remain subclinical. BPVT is best diagnosed by multiphase gated CT angiography as the presence of reduced leaflet motion (RELM) and hypoattenuating aortic leaflet thickening (HALT). Whilst CT is used to exclude BPVT in symptomatic patients and those with increased valve gradient, the value of screening and prophylactic anticoagulation is debatable.

U2 - 10.1016/j.crad.2020.08.015

DO - 10.1016/j.crad.2020.08.015

M3 - Article

SN - 0009-9260

JO - Clinical Radiology

JF - Clinical Radiology

ER -

Bioprosthetic valve thrombosis and degeneration following transcatheter aortic valve implantation (TAVI)

Abstract

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