CCR2B receptor antagonists: Conversion of a weak HTS hit to a potent lead compound

Ian T. Forbes, David G. Cooper, Emma K. Dodds, Deirdre M. B. Hickey, Robert J. Ife, Malcolm Meeson, Martin Stockley, Theo Berkhout, Jayneeta Gohil, Pieter H. E. Groot, Kitty E. Moores

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

A weak HTS hit at the CCR2B receptor has been converted into a potent antagonist by array SAR studies. Selectivity over the closely related CCR5 receptor is also achieved. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1803-1806
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number16
DOIs
Publication statusPublished - 21 Aug 2000

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