Centrifugally automated solid-hase purification of RNA

Nikolay Dimov, Jennifer Gaughran, Darren Mc Auley, David Boyle, David J. Kinahan, Jens Ducree

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)


The purity and integrity of RNA after extraction from a biosample like blood are critical for both downstream analysis and development of on-chip diagnostics. We report for the first time on a fully centrifugally automated solidphase purification of RNA on an integrated microfluidic disc with sequential release of on-board reagents. Building on our earlier work the system successfully concatenates event-triggered valving and centrifugally controlled routing in order to collect purified RNA separately from the aqueous and organic wastes. In this article two-stage purification of RNA and sample conditioning through novel high-frequency release and hybrid event-triggered release valves is demonstrated.

Original languageEnglish
Title of host publicationMEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Number of pages4
ISBN (Print)9781479935086
Publication statusPublished - 2014
Event27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014 - San Francisco, CA, United States
Duration: 26 Jan 201430 Jan 2014


Conference27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
Country/TerritoryUnited States
CitySan Francisco, CA


Dive into the research topics of 'Centrifugally automated solid-hase purification of RNA'. Together they form a unique fingerprint.

Cite this