Cerebellar output controls generalized spike-and-wave discharge occurence

Lieke Kros, Oscar Eelkman Rooda, Jochen Spanke, Parimala Alva, Marijn van Dongen, Athanasios Karapatis, Else Tolner, Christos Strydis, N. Davey, Beerend Winkelman, Mario Negrello, Wouter Serdijn, Volker Steuber, Arn van den Maagdenberg, Chris I. De Zeeuw, Freek E. Hoebeek

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72 Citations (Scopus)
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Abstract

Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical oscillations through their innervation of a wide variety of thalamic nuclei, is effective in controlling absence seizures
Original languageEnglish
Pages (from-to)1027-1049
JournalAnnals of Neurology
Volume77
Issue number6
Early online date11 Mar 2015
DOIs
Publication statusPublished - 1 Jun 2015

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