Cerebellar output controls generalized spike-and-wave discharge occurence

Lieke Kros; Oscar Eelkman Rooda; Jochen Spanke; Parimala Alva; Marijn van Dongen; Athanasios Karapatis; Else Tolner; Christos Strydis; N. Davey; Beerend Winkelman; Mario Negrello; Wouter Serdijn; Volker Steuber; Arn van den Maagdenberg; Chris I. De Zeeuw; Freek E. Hoebeek

doi:10.1002/ana.24399

Cerebellar output controls generalized spike-and-wave discharge occurence

Lieke Kros, Oscar Eelkman Rooda, Jochen Spanke, Parimala Alva, Marijn van Dongen, Athanasios Karapatis, Else Tolner, Christos Strydis, N. Davey, Beerend Winkelman, Mario Negrello, Wouter Serdijn, Volker Steuber, Arn van den Maagdenberg, Chris I. De Zeeuw, Freek E. Hoebeek

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Abstract

Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical oscillations through their innervation of a wide variety of thalamic nuclei, is effective in controlling absence seizures

Original language	English
Pages (from-to)	1027-1049
Journal	Annals of Neurology
Volume	77
Issue number	6
Early online date	11 Mar 2015
DOIs	https://doi.org/10.1002/ana.24399
Publication status	Published - 1 Jun 2015

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10.1002/ana.24399Licence: CC BY-NC-ND

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© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made
Final published version, 856 KBLicence: CC BY-NC-ND

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Kros, L., Eelkman Rooda, O., Spanke, J., Alva, P., van Dongen, M., Karapatis, A., Tolner, E., Strydis, C., Davey, N., Winkelman, B., Negrello, M., Serdijn, W., Steuber, V., van den Maagdenberg, A., De Zeeuw, C. I., & Hoebeek, F. E. (2015). Cerebellar output controls generalized spike-and-wave discharge occurence. Annals of Neurology, 77(6), 1027-1049. https://doi.org/10.1002/ana.24399

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title = "Cerebellar output controls generalized spike-and-wave discharge occurence",

abstract = "Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical oscillations through their innervation of a wide variety of thalamic nuclei, is effective in controlling absence seizures",

author = "Lieke Kros and {Eelkman Rooda}, Oscar and Jochen Spanke and Parimala Alva and {van Dongen}, Marijn and Athanasios Karapatis and Else Tolner and Christos Strydis and N. Davey and Beerend Winkelman and Mario Negrello and Wouter Serdijn and Volker Steuber and {van den Maagdenberg}, Arn and {De Zeeuw}, {Chris I.} and Hoebeek, {Freek E.}",

note = "{\textcopyright} 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.",

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Kros, L, Eelkman Rooda, O, Spanke, J, Alva, P, van Dongen, M, Karapatis, A, Tolner, E, Strydis, C, Davey, N, Winkelman, B, Negrello, M, Serdijn, W, Steuber, V, van den Maagdenberg, A, De Zeeuw, CI & Hoebeek, FE 2015, 'Cerebellar output controls generalized spike-and-wave discharge occurence', Annals of Neurology, vol. 77, no. 6, pp. 1027-1049. https://doi.org/10.1002/ana.24399

TY - JOUR

T1 - Cerebellar output controls generalized spike-and-wave discharge occurence

AU - Kros, Lieke

AU - Eelkman Rooda, Oscar

AU - Spanke, Jochen

AU - Alva, Parimala

AU - van Dongen, Marijn

AU - Karapatis, Athanasios

AU - Tolner, Else

AU - Strydis, Christos

AU - Davey, N.

AU - Winkelman, Beerend

AU - Negrello, Mario

AU - Serdijn, Wouter

AU - Steuber, Volker

AU - van den Maagdenberg, Arn

AU - De Zeeuw, Chris I.

AU - Hoebeek, Freek E.

N1 - © 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical oscillations through their innervation of a wide variety of thalamic nuclei, is effective in controlling absence seizures

AB - Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical oscillations through their innervation of a wide variety of thalamic nuclei, is effective in controlling absence seizures

U2 - 10.1002/ana.24399

DO - 10.1002/ana.24399

M3 - Article

SN - 1531-8249

VL - 77

SP - 1027

EP - 1049

JO - Annals of Neurology

JF - Annals of Neurology

IS - 6

ER -

Cerebellar output controls generalized spike-and-wave discharge occurence

Abstract

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