Characterisation of copper oxide nanoparticles for antimicrobial applications

Guogang Ren; D. Hu; E.W.C. Cheng; M.A. Vargas-Reus; P. Reip; R. Allaker

doi:10.1016/j.ijantimicag.2008.12.004

Characterisation of copper oxide nanoparticles for antimicrobial applications

Guogang Ren, D. Hu, E.W.C. Cheng, M.A. Vargas-Reus, P. Reip, R. Allaker

Research output: Contribution to journal › Article › peer-review

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Abstract

Copper oxide (CuO) nanoparticles were characterised and investigated with respect to potential antimicrobial applications. It was found that nanoscaled CuO, generated by thermal plasma technology, contains traces of pure Cu and Cu2O nanoparticles. Transmission electron microscopy (TEM) demonstrated particle sizes in the range 20–95 nm. TEM energy dispersive spectroscopy gave the ratio of copper to oxygen elements as 54.18% to 45.26%. The mean surface area was determined as 15.69 m2/g by Brunau–Emmet–Teller (BET) analysis. CuO nanoparticles in suspension showed activity against a range of bacterial pathogens, including meticillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli, with minimum bactericidal concentrations (MBCs) ranging from 100 μg/mL to 5000 μg/mL. The ability of CuO nanoparticles to reduce bacterial populations to zero was enhanced in the presence of sub-MBC concentrations of silver nanoparticles. Studies of CuO nanoparticles incorporated into polymers suggest release of ions may be required for optimum killing.

Original language	English
Pages (from-to)	587-590
Journal	International Journal of Antimicrobial Agents
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.ijantimicag.2008.12.004
Publication status	Published - 2009

Keywords

nanoparticle
copper oxide
CuO
antimicrobial
cross-infection control

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10.1016/j.ijantimicag.2008.12.004

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title = "Characterisation of copper oxide nanoparticles for antimicrobial applications",

abstract = "Copper oxide (CuO) nanoparticles were characterised and investigated with respect to potential antimicrobial applications. It was found that nanoscaled CuO, generated by thermal plasma technology, contains traces of pure Cu and Cu2O nanoparticles. Transmission electron microscopy (TEM) demonstrated particle sizes in the range 20–95 nm. TEM energy dispersive spectroscopy gave the ratio of copper to oxygen elements as 54.18% to 45.26%. The mean surface area was determined as 15.69 m2/g by Brunau–Emmet–Teller (BET) analysis. CuO nanoparticles in suspension showed activity against a range of bacterial pathogens, including meticillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli, with minimum bactericidal concentrations (MBCs) ranging from 100 μg/mL to 5000 μg/mL. The ability of CuO nanoparticles to reduce bacterial populations to zero was enhanced in the presence of sub-MBC concentrations of silver nanoparticles. Studies of CuO nanoparticles incorporated into polymers suggest release of ions may be required for optimum killing.",

keywords = "nanoparticle, copper oxide, CuO, antimicrobial, cross-infection control",

author = "Guogang Ren and D. Hu and E.W.C. Cheng and M.A. Vargas-Reus and P. Reip and R. Allaker",

note = "Original article can be found at : http://www.sciencedirect.com/ Copyright Elsevier [Full text of this article is not available in the UHRA]",

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doi = "10.1016/j.ijantimicag.2008.12.004",

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T1 - Characterisation of copper oxide nanoparticles for antimicrobial applications

AU - Ren, Guogang

AU - Hu, D.

AU - Cheng, E.W.C.

AU - Vargas-Reus, M.A.

AU - Reip, P.

AU - Allaker, R.

N1 - Original article can be found at : http://www.sciencedirect.com/ Copyright Elsevier [Full text of this article is not available in the UHRA]

PY - 2009

Y1 - 2009

N2 - Copper oxide (CuO) nanoparticles were characterised and investigated with respect to potential antimicrobial applications. It was found that nanoscaled CuO, generated by thermal plasma technology, contains traces of pure Cu and Cu2O nanoparticles. Transmission electron microscopy (TEM) demonstrated particle sizes in the range 20–95 nm. TEM energy dispersive spectroscopy gave the ratio of copper to oxygen elements as 54.18% to 45.26%. The mean surface area was determined as 15.69 m2/g by Brunau–Emmet–Teller (BET) analysis. CuO nanoparticles in suspension showed activity against a range of bacterial pathogens, including meticillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli, with minimum bactericidal concentrations (MBCs) ranging from 100 μg/mL to 5000 μg/mL. The ability of CuO nanoparticles to reduce bacterial populations to zero was enhanced in the presence of sub-MBC concentrations of silver nanoparticles. Studies of CuO nanoparticles incorporated into polymers suggest release of ions may be required for optimum killing.

AB - Copper oxide (CuO) nanoparticles were characterised and investigated with respect to potential antimicrobial applications. It was found that nanoscaled CuO, generated by thermal plasma technology, contains traces of pure Cu and Cu2O nanoparticles. Transmission electron microscopy (TEM) demonstrated particle sizes in the range 20–95 nm. TEM energy dispersive spectroscopy gave the ratio of copper to oxygen elements as 54.18% to 45.26%. The mean surface area was determined as 15.69 m2/g by Brunau–Emmet–Teller (BET) analysis. CuO nanoparticles in suspension showed activity against a range of bacterial pathogens, including meticillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli, with minimum bactericidal concentrations (MBCs) ranging from 100 μg/mL to 5000 μg/mL. The ability of CuO nanoparticles to reduce bacterial populations to zero was enhanced in the presence of sub-MBC concentrations of silver nanoparticles. Studies of CuO nanoparticles incorporated into polymers suggest release of ions may be required for optimum killing.

KW - nanoparticle

KW - copper oxide

KW - CuO

KW - antimicrobial

KW - cross-infection control

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DO - 10.1016/j.ijantimicag.2008.12.004

M3 - Article

SN - 0924-8579

VL - 33

SP - 587

EP - 590

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 6

ER -

Characterisation of copper oxide nanoparticles for antimicrobial applications

Abstract

Keywords

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