Clinical cytogenetics in pediatric acute leukemia: an update

Maria Braoudaki; Fotini Tzortzatou-Stathopoulou

doi:10.1016/j.clml.2012.04.004

Clinical cytogenetics in pediatric acute leukemia: an update

Maria Braoudaki, Fotini Tzortzatou-Stathopoulou

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

Abstract

Pediatric acute leukemias are generally characterized by recurrent numerical and structural chromosomal abnormalities, which are thought to be specifically associated with diagnosis and prognosis of both childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The identification of those chromosomal aberrations is clinically important because they are considered significant risk-stratifying markers. However there have been several instances in which they remain undetectable, possibly due to the low resolution of most genetic screening tools used. In the present review, the clinical significance of most chromosomal aberrations associated with pediatric ALL and AML as well as the current technology used for their identification is discussed.

Original language	English
Pages (from-to)	230-237
Number of pages	8
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	12
Issue number	4
Early online date	19 May 2012
DOIs	https://doi.org/10.1016/j.clml.2012.04.004
Publication status	Published - 1 Aug 2012

Keywords

Adolescent
Child
Child, Preschool
Chromosome Aberrations
Cytogenetic Analysis
Humans
Karyotyping
Leukemia, Myeloid, Acute/diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis

Access to Document

10.1016/j.clml.2012.04.004Licence: Other

Cite this

@article{160c53a6fae34f5db3575ddf8a7c14cd,

title = "Clinical cytogenetics in pediatric acute leukemia: an update",

abstract = "Pediatric acute leukemias are generally characterized by recurrent numerical and structural chromosomal abnormalities, which are thought to be specifically associated with diagnosis and prognosis of both childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The identification of those chromosomal aberrations is clinically important because they are considered significant risk-stratifying markers. However there have been several instances in which they remain undetectable, possibly due to the low resolution of most genetic screening tools used. In the present review, the clinical significance of most chromosomal aberrations associated with pediatric ALL and AML as well as the current technology used for their identification is discussed.",

keywords = "Adolescent, Child, Child, Preschool, Chromosome Aberrations, Cytogenetic Analysis, Humans, Karyotyping, Leukemia, Myeloid, Acute/diagnosis, Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis",

author = "Maria Braoudaki and Fotini Tzortzatou-Stathopoulou",

year = "2012",

month = aug,

day = "1",

doi = "10.1016/j.clml.2012.04.004",

language = "English",

volume = "12",

pages = "230--237",

journal = "Clinical Lymphoma, Myeloma and Leukemia",

issn = "2152-2650",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Clinical cytogenetics in pediatric acute leukemia

T2 - an update

AU - Braoudaki, Maria

AU - Tzortzatou-Stathopoulou, Fotini

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Pediatric acute leukemias are generally characterized by recurrent numerical and structural chromosomal abnormalities, which are thought to be specifically associated with diagnosis and prognosis of both childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The identification of those chromosomal aberrations is clinically important because they are considered significant risk-stratifying markers. However there have been several instances in which they remain undetectable, possibly due to the low resolution of most genetic screening tools used. In the present review, the clinical significance of most chromosomal aberrations associated with pediatric ALL and AML as well as the current technology used for their identification is discussed.

AB - Pediatric acute leukemias are generally characterized by recurrent numerical and structural chromosomal abnormalities, which are thought to be specifically associated with diagnosis and prognosis of both childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The identification of those chromosomal aberrations is clinically important because they are considered significant risk-stratifying markers. However there have been several instances in which they remain undetectable, possibly due to the low resolution of most genetic screening tools used. In the present review, the clinical significance of most chromosomal aberrations associated with pediatric ALL and AML as well as the current technology used for their identification is discussed.

KW - Adolescent

KW - Child

KW - Child, Preschool

KW - Chromosome Aberrations

KW - Cytogenetic Analysis

KW - Humans

KW - Karyotyping

KW - Leukemia, Myeloid, Acute/diagnosis

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis

U2 - 10.1016/j.clml.2012.04.004

DO - 10.1016/j.clml.2012.04.004

M3 - Review article

C2 - 22609262

SN - 2152-2650

VL - 12

SP - 230

EP - 237

JO - Clinical Lymphoma, Myeloma and Leukemia

JF - Clinical Lymphoma, Myeloma and Leukemia

IS - 4

ER -

Clinical cytogenetics in pediatric acute leukemia: an update

Abstract

Keywords

Access to Document

Fingerprint

Cite this