Clinical outcomes and quality of life in elderly patients on peritoneal dialysis versus hemodialysis

Susan A.C. Harris, Donna L. Lamping, Edwina A. Brown, Niculae Constantinovici, M. Phillips, G. Barnes, D. Keir, E. Clutterbuck, S. Dickens, R. Greenwood, K. Farrington, A. Abdullah, S. Chandna, B. Saunders, G. Rehsi, D. Taube, A. Palmer, A. Lawrence, R. Proudfoot, S. CanoJ. Litaker, A. Steriu

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135 Citations (Scopus)


Objective: To compare clinical outcomes and quality of life (QOL) in elderly patients on peritoneal dialysis (PD) and hemodialysis (HD) in the North Thames Dialysis Study. Design: A 12-month prospective cohort study. Setting: Four hospital-based renal units in London, UK. Patients: 174 patients that were 70 years or older at the start of dialysis, separated into two cohorts: 78 new patients (36 PD, 42 HD) that were recruited after 90 days of chronic dialysis; and 96 stock patients (42 PD, 54 HD) that were already on dialysis during the recruitment period. Main Outcome Measures: 12-month survival and hospitalization rate, and QOL assessed at baseline and at 6 and 12 months by the SF-36 and the Symptoms/Problems scale of the Kidney Disease Quality of Life Questionnaire (KDQOL). Results: Peritoneal dialysis and HD patients were similar for sociodemographic and clinical characteristics. Annual mortality and hospitalization rates in PD versus HD patients were 26.1 versus 26.4 deaths/100 person-years and 1.9 versus 2.0 admissions/person-year, respectively. Adjusted relative risks showed no effect of modality on clinical outcomes. Multiple linear regression analyses of QOL at baseline showed similar SF-36 scores between PD and HD patients, but higher KDQOL scores in PD patients (3.5 points higher, 95% confidence interval 0.3 - 6.6). There was, however, no effect of dialysis modality on QOL at 6 or 12 months. Conclusions: Clinical outcomes and QOL are similar in elderly people on PD and HD. Peritoneal dialysis is a viable option for more than a carefully selected minority of elderly people requiring dialysis.

Original languageEnglish
Pages (from-to)463-470
Number of pages8
JournalPeritoneal Dialysis International
Issue number4
Publication statusPublished - 1 Jul 2002


  • Dialysis modality
  • Elderly patients
  • Hemodialysis
  • Hospitalization
  • Quality of life
  • Survival


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