Comparison of energy estimates in chronic kidney disease using doubly-labelled water

S Sridharan, J Wong, E Vilar, K Farrington

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)
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BACKGROUND: Total energy expenditure (TEE) is estimated in clinical practice as a combined measure of resting energy expenditure and physical activity level. Commonly available questionnaires to estimate physical activity level have not been validated in patients with kidney disease using the doubly-labelled water method.

METHODS: This prospective, cross-sectional study was conducted on 40 patients with chronic kidney disease stages 1-5 with the objective of validating two physical activity questionnaires: the Recent Physical Activity Questionnaire (RPAQ) and the Stanford 7-day recall questionnaire. TEE was measured using doubly-labelled water technique. TEE was also estimated using predicted resting energy expenditure and estimated physical activity measures from the questionnaires.

RESULTS: Measured TEE correlated better with TEE estimated from RPAQ compared to that from the Stanford questionnaire. In Bland-Altman analysis, TEE estimated from RPAQ had the least bias and narrower limits of agreement compared to the measured TEE. A metabolic equivalent of task value of 1.3 for the unaccounted time in RPAQ provided the best approximation of estimated TEE to the measured TEE.

CONCLUSIONS: RPAQ is an acceptable questionnaire tool for assessing physical activity level in patients with chronic kidney disease.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalJournal of human nutrition and dietetics : the official journal of the British Dietetic Association
Issue number1
Early online date15 Jul 2015
Publication statusPublished - 27 Jan 2016


  • Adult
  • Aged
  • Body Mass Index
  • Body Weight
  • Cross-Sectional Studies
  • Energy Metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motor Activity
  • Prospective Studies
  • Renal Insufficiency, Chronic
  • Surveys and Questionnaires
  • Water


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