Comparison of somatodendritic and axon terminal dopamine release in the ventral tegmental area and the nucleus accumbens

Mahmoud M. Iravani, R. Muscat, Z. L. Kruk

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Fast cyclic voltammetry at a carbon fibre microelectrode was used to measure dopamine release following electrical or chemical stimulation in rat brain slices incorporating either the ventral tegmental area or the core region of the nucleus accumbens. Electrical or chemical stimulation gave clear voltammetric signals which corresponded to dopamine; less dopamine was released in the ventral tegmental area than in the nucleus accumbens. In contrast to the nucleus accumbens, electrically stimulated dopamine release in the ventral tegmental area was not sensitive to tetrodotoxin, was not modified by the presence of dopamine uptake inhibitors, or agonist or blockers acting at dopamine D-2 autoreceptors.

Original languageEnglish
Pages (from-to)1025-1037
Number of pages13
JournalNeuroscience
Volume70
Issue number4
DOIs
Publication statusPublished - Feb 1996

Keywords

  • fast cyclic voltammetry
  • somatodendritic release
  • electrical stimulation
  • chemical stimulation
  • RAT SUBSTANTIA NIGRA
  • GAMMA-AMINOBUTYRIC-ACID
  • FAST CYCLIC VOLTAMMETRY
  • INVIVO MICRODIALYSIS
  • ENDOGENOUS DOPAMINE
  • DENDRITIC DOPAMINE
  • PARS-RETICULATA
  • BRAIN-SLICES
  • NIGROSTRIATAL NEURONS
  • SYSTEMIC AMPHETAMINE

Fingerprint

Dive into the research topics of 'Comparison of somatodendritic and axon terminal dopamine release in the ventral tegmental area and the nucleus accumbens'. Together they form a unique fingerprint.

Cite this