Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection

Jane Freeman; Simon D. Baines; Daniela Jabes; Mark H. Wilcox

doi:10.1093/jac/dki321

Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection

Jane Freeman, Simon D. Baines, Daniela Jabes, Mark H. Wilcox

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.

Original language	English
Pages (from-to)	717-25
Number of pages	9
Journal	Journal of Antimicrobial Chemotherapy
Volume	56
Issue number	4
DOIs	https://doi.org/10.1093/jac/dki321
Publication status	Published - Sept 2005

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title = "Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection",

abstract = "Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.",

author = "Jane Freeman and Baines, {Simon D.} and Daniela Jabes and Wilcox, {Mark H.}",

year = "2005",

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AU - Freeman, Jane

AU - Baines, Simon D.

AU - Jabes, Daniela

AU - Wilcox, Mark H.

PY - 2005/9

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N2 - Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.

AB - Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.

U2 - 10.1093/jac/dki321

DO - 10.1093/jac/dki321

M3 - Article

C2 - 16143709

SN - 0305-7453

VL - 56

SP - 717

EP - 725

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 4

ER -

Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection

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