Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection

Jane Freeman; Simon D. Baines; Daniela Jabes; Mark H. Wilcox

doi:10.1093/jac/dki321

Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection

Jane Freeman
, Simon D. Baines
, Daniela Jabes
, Mark H. Wilcox

Research output: Contribution to journal › Article › peer-review

131 Citations (Scopus)

Abstract

Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.

Original language	English
Pages (from-to)	717-25
Number of pages	9
Journal	Journal of Antimicrobial Chemotherapy
Volume	56
Issue number	4
DOIs	https://doi.org/10.1093/jac/dki321
Publication status	Published - Sept 2005

Access to Document

10.1093/jac/dki321

Cite this

@article{839ed29bb5464fed8f1641b19a5ee431,

title = "Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection",

abstract = "Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.",

author = "Jane Freeman and Baines, \{Simon D.\} and Daniela Jabes and Wilcox, \{Mark H.\}",

year = "2005",

month = sep,

doi = "10.1093/jac/dki321",

language = "English",

volume = "56",

pages = "717--25",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press (OUP)",

number = "4",

}

TY - JOUR

T1 - Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection

AU - Freeman, Jane

AU - Baines, Simon D.

AU - Jabes, Daniela

AU - Wilcox, Mark H.

PY - 2005/9

Y1 - 2005/9

N2 - Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.

AB - Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models of clindamycin-induced CDI.

U2 - 10.1093/jac/dki321

DO - 10.1093/jac/dki321

M3 - Article

C2 - 16143709

SN - 0305-7453

VL - 56

SP - 717

EP - 725

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 4

ER -

Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection

Abstract

Access to Document

Fingerprint

Cite this