Cu-bearing steel reduce inflammation after stent implantation

Jinzhao Li, Ling Ren, Shuyuan Zhang, Guogang Ren, Ke Yang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
25 Downloads (Pure)


Copper (Cu)-bearing stainless steel with release of Cu(2+) ions is a novel material for coronary stents that could reduce the in-stent restenosis after the stent implantation. The inflammation has been recently recognized as an important factor to smooth muscle cells proliferation, thrombosis, and hence the restenosis post-angioplasty. The objective of this study is to further investigate the effect and relevant mechanism of Cu-bearing stainless steel (316L-Cu SS) on the inflammation reaction after stent implantation. The results demonstrated that, compared with commercial coronary stent material (316L SS), 316L-Cu SS could inhibit the inflammation caused by endothelial dysfunction through blockading the inflammatory factors (TNF-α, IL-1β, 6, 8), which would then reduce the recruitment and infiltration of leukocytes, rather than have direct effect on leukocytes. This finding further explained the reduction effect of 316L-Cu SS on in-stent restenosis from a novel view.

Original languageEnglish
Article number114
Number of pages4
JournalJournal of Material Science: Materials in Medicine
Issue number2
Early online date11 Feb 2015
Publication statusPublished - Feb 2015


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