Damage to the right insula disrupts the perception of affective touch

Louise P Kirsch; Sahba Besharati; Christina Papadaki; Laura Crucianelli; Sara Bertagnoli; Nick Ward; Valentina Moro; Paul M Jenkinson; Aikaterini Fotopoulou

doi:10.7554/eLife.47895

Damage to the right insula disrupts the perception of affective touch

Louise P Kirsch, Sahba Besharati, Christina Papadaki, Laura Crucianelli, Sara Bertagnoli, Nick Ward, Valentina Moro, Paul M Jenkinson, Aikaterini Fotopoulou

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Abstract

Specific, peripheral C-tactile afferents contribute to the perception of tactile pleasure, but the brain areas involved in their processing remain debated. We report the first human lesion study on the perception of C-tactile touch in right hemisphere stroke patients (N = 59), revealing that right posterior and anterior insula lesions reduce tactile, contralateral and ipsilateral pleasantness sensitivity, respectively. These findings corroborate previous imaging studies regarding the role of the posterior insula in the perception of affective touch. However, our findings about the crucial role of the anterior insula for ipsilateral affective touch perception open new avenues of enquiry regarding the cortical organization of this tactile system.

Original language	English
Article number	e47895
Number of pages	17
Journal	eLife
Volume	9
DOIs	https://doi.org/10.7554/eLife.47895
Publication status	Published - 24 Jan 2020

Keywords

Affective touch
CT system
Insula
Interoception
Lesion mapping

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10.7554/eLife.47895Licence: CC BY

elife-47895-v2
© 2020 Kirsch et al. This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
Final published version, 1.2 MBLicence: CC BY

Cite this

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abstract = "Specific, peripheral C-tactile afferents contribute to the perception of tactile pleasure, but the brain areas involved in their processing remain debated. We report the first human lesion study on the perception of C-tactile touch in right hemisphere stroke patients (N = 59), revealing that right posterior and anterior insula lesions reduce tactile, contralateral and ipsilateral pleasantness sensitivity, respectively. These findings corroborate previous imaging studies regarding the role of the posterior insula in the perception of affective touch. However, our findings about the crucial role of the anterior insula for ipsilateral affective touch perception open new avenues of enquiry regarding the cortical organization of this tactile system.",

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AU - Papadaki, Christina

AU - Crucianelli, Laura

AU - Bertagnoli, Sara

AU - Ward, Nick

AU - Moro, Valentina

AU - Jenkinson, Paul M

AU - Fotopoulou, Aikaterini

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N2 - Specific, peripheral C-tactile afferents contribute to the perception of tactile pleasure, but the brain areas involved in their processing remain debated. We report the first human lesion study on the perception of C-tactile touch in right hemisphere stroke patients (N = 59), revealing that right posterior and anterior insula lesions reduce tactile, contralateral and ipsilateral pleasantness sensitivity, respectively. These findings corroborate previous imaging studies regarding the role of the posterior insula in the perception of affective touch. However, our findings about the crucial role of the anterior insula for ipsilateral affective touch perception open new avenues of enquiry regarding the cortical organization of this tactile system.

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Damage to the right insula disrupts the perception of affective touch

Abstract

Keywords

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