Derivative-ratio spectrophotometric method for the determination of ternary mixture of aspirin, paracetamol and salicylic acid

Fawzi A El-Yazbi, Hassan H Hammud, Sulaf Assi

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    21 Citations (Scopus)

    Abstract

    A derivative spectrophotometric method was developed for the assay of a ternary mixture of aspirin (ASP), paracetamol (PAR) and salicylic acid (SAL). The method is based on the use of the first and second derivatives of the ratio spectra and measurement at zero-crossing wavelengths. The ratio spectra were obtained by dividing the absorption spectrum of the mixture by that of one of the components. The concentration of the other components are then determined from their respective calibration curves treated similarly. The described method was applied for the determination of these combinations in synthetic mixtures and dosage forms. The results obtained were accurate and precise.
    Original languageEnglish
    Pages (from-to)275-8
    Number of pages4
    JournalSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
    Volume68
    Issue number2
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Acetaminophen
    • Aspirin
    • Drug Combinations
    • Salicylic Acid
    • Spectrophotometry
    • Spectrophotometry, Ultraviolet

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