TY - JOUR
T1 - Design and baseline characteristics of the Food4Me study
T2 - a web-based randomised controlled trial of personalised nutrition in seven European countries
AU - Celis-Morales, Carlos
AU - Livingstone, Katherine M.
AU - Marsaux, Cyril F.M.
AU - Forster, Hannah
AU - O’Donovan, Clare B.
AU - Woolhead, Clara
AU - Macready, Anna L.
AU - Fallaize, Rosalind
AU - Navas-Carretero, Santiago
AU - San-Cristobal, Rodrigo
AU - Kolossa, Silvia
AU - Hartwig, Kai
AU - Tsirigoti, Lydia
AU - Lambrinou, Christina P.
AU - Moschonis, George
AU - Godlewska, Magdalena
AU - Surwiłło, Agnieszka
AU - Grimaldi, Keith
AU - Bouwman, Jildau
AU - Daly, E. J.
AU - Akujobi, Victor
AU - O’Riordan, Rick
AU - Hoonhout, Jettie
AU - Claassen, Arjan
AU - Hoeller, Ulrich
AU - Gundersen, Thomas E.
AU - Kaland, Siv E.
AU - Matthews, John N.S.
AU - Manios, Yannis
AU - Traczyk, Iwona
AU - Drevon, Christian A.
AU - Gibney, Eileen R.
AU - Brennan, Lorraine
AU - Walsh, Marianne C.
AU - Lovegrove, Julie A.
AU - Alfredo Martinez, J.
AU - Saris, Wim H.M.
AU - Daniel, Hannelore
AU - Gibney, Mike
AU - Mathers, John C.
N1 - Date of Acceptance: 01/12/2014
PY - 2015/1/10
Y1 - 2015/1/10
N2 - Improving lifestyle behaviours has considerable potential for reducing the global burden of non-communicable diseases, promoting better health across the life-course and increasing well-being. However, realising this potential will require the development, testing and implementation of much more effective behaviour change interventions than are used conventionally. Therefore, the aim of this study was to conduct a multi-centre, web-based, proof-of-principle study of personalised nutrition (PN) to determine whether providing more personalised dietary advice leads to greater improvements in eating patterns and health outcomes compared to conventional population-based advice. A total of 5,562 volunteers were screened across seven European countries; the first 1,607 participants who fulfilled the inclusion criteria were recruited into the trial. Participants were randomly assigned to one of the following intervention groups for a 6-month period: Level 0—control group—receiving conventional, non-PN advice; Level 1—receiving PN advice based on dietary intake data alone; Level 2—receiving PN advice based on dietary intake and phenotypic data; and Level 3—receiving PN advice based on dietary intake, phenotypic and genotypic data. A total of 1,607 participants had a mean age of 39.8 years (ranging from 18 to 79 years). Of these participants, 60.9 % were women and 96.7 % were from white-European background. The mean BMI for all randomised participants was 25.5 kg m−2, and 44.8 % of the participants had a BMI ≥ 25.0 kg m−2. Food4Me is the first large multi-centre RCT of web-based PN. The main outcomes from the Food4Me study will be submitted for publication during 2015.
AB - Improving lifestyle behaviours has considerable potential for reducing the global burden of non-communicable diseases, promoting better health across the life-course and increasing well-being. However, realising this potential will require the development, testing and implementation of much more effective behaviour change interventions than are used conventionally. Therefore, the aim of this study was to conduct a multi-centre, web-based, proof-of-principle study of personalised nutrition (PN) to determine whether providing more personalised dietary advice leads to greater improvements in eating patterns and health outcomes compared to conventional population-based advice. A total of 5,562 volunteers were screened across seven European countries; the first 1,607 participants who fulfilled the inclusion criteria were recruited into the trial. Participants were randomly assigned to one of the following intervention groups for a 6-month period: Level 0—control group—receiving conventional, non-PN advice; Level 1—receiving PN advice based on dietary intake data alone; Level 2—receiving PN advice based on dietary intake and phenotypic data; and Level 3—receiving PN advice based on dietary intake, phenotypic and genotypic data. A total of 1,607 participants had a mean age of 39.8 years (ranging from 18 to 79 years). Of these participants, 60.9 % were women and 96.7 % were from white-European background. The mean BMI for all randomised participants was 25.5 kg m−2, and 44.8 % of the participants had a BMI ≥ 25.0 kg m−2. Food4Me is the first large multi-centre RCT of web-based PN. The main outcomes from the Food4Me study will be submitted for publication during 2015.
KW - Genotype
KW - Personalised nutrition
KW - Phenotype
KW - Randomised controlled trial
KW - Web-based
U2 - 10.1007/s12263-014-0450-2
DO - 10.1007/s12263-014-0450-2
M3 - Article
SN - 1555-8932
VL - 10
JO - Genes and Nutrition
JF - Genes and Nutrition
IS - 1
M1 - 450
ER -