Abstract
A series of novel diketones were designed and
synthesised in an attempt to develop potent antimicrobial
agents. Their structures were confirmed by spectroscopic
techniques i.e. 1H and 13C-NMR, IR and LC-MS. The
minimum inhibitory concentration (MIC) was determined
against a wide range of bacteria using two fold micro
broth dilution method. Among the test Compounds DK2,
DK6, DK7, DK11, DK12, DK16 and DK17 were found to
have excellent activity against all Gram positive bacteria
with MIC values ranging 16-0.1μg/ml. The in vitro
cytotoxity of all the active compounds was assessed by
MTT clorimetric assay. The bioactive compounds
exhibited IC50 values against Caco-2 cells rainging 64-8ug/ml
synthesised in an attempt to develop potent antimicrobial
agents. Their structures were confirmed by spectroscopic
techniques i.e. 1H and 13C-NMR, IR and LC-MS. The
minimum inhibitory concentration (MIC) was determined
against a wide range of bacteria using two fold micro
broth dilution method. Among the test Compounds DK2,
DK6, DK7, DK11, DK12, DK16 and DK17 were found to
have excellent activity against all Gram positive bacteria
with MIC values ranging 16-0.1μg/ml. The in vitro
cytotoxity of all the active compounds was assessed by
MTT clorimetric assay. The bioactive compounds
exhibited IC50 values against Caco-2 cells rainging 64-8ug/ml
| Original language | English |
|---|---|
| Publication status | Published - 26 Nov 2015 |
| Event | Antibiotic Resistance Mechanisms Workshop (ARM 2015), Birmingham, UK - Duration: 26 Nov 2015 → 27 Nov 2015 |
Conference
| Conference | Antibiotic Resistance Mechanisms Workshop (ARM 2015), Birmingham, UK |
|---|---|
| Abbreviated title | ARM(2015) |
| Period | 26/11/15 → 27/11/15 |