Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

Rahim Kanji; Ying X. Gue; Mohamed F. Farag; Neil H. Spencer; Nicola J. Mutch; Diana A. Gorog

doi:10.1016/j.jacbts.2022.05.007

Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

Rahim Kanji, Ying X. Gue, Mohamed F. Farag, Neil H. Spencer, Nicola J. Mutch, Diana A. Gorog

Research output: Contribution to journal › Article › peer-review

Abstract

Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis.

Original language	English
Journal	JACC: Basic to Translational Science
Early online date	24 Aug 2022
DOIs	https://doi.org/10.1016/j.jacbts.2022.05.007
Publication status	E-pub ahead of print - 24 Aug 2022

Access to Document

10.1016/j.jacbts.2022.05.007Licence: CC BY

Cite this

@article{98b8fe4267804b04b1fa9a416aedd5a6,

title = "Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction",

abstract = "Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis.",

author = "Rahim Kanji and Gue, {Ying X.} and Farag, {Mohamed F.} and Spencer, {Neil H.} and Mutch, {Nicola J.} and Gorog, {Diana A.}",

note = "{\textcopyright} 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.",

year = "2022",

month = aug,

day = "24",

doi = "10.1016/j.jacbts.2022.05.007",

language = "English",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier",

}

TY - JOUR

T1 - Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

AU - Kanji, Rahim

AU - Gue, Ying X.

AU - Farag, Mohamed F.

AU - Spencer, Neil H.

AU - Mutch, Nicola J.

AU - Gorog, Diana A.

PY - 2022/8/24

Y1 - 2022/8/24

N2 - Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis.

AB - Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis.

U2 - 10.1016/j.jacbts.2022.05.007

DO - 10.1016/j.jacbts.2022.05.007

M3 - Article

SN - 2452-302X

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

ER -

Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

Abstract

Access to Document

Fingerprint

Cite this