Abstract
AIM: To identify factors contributing to the development and progression of left ventricular hypertrophy (LVH) in patients on high-flux haemodialysis.
METHOD: Fifty patients without clinical cardiac disease underwent baseline echocardiography, related measurements and follow-up studies 6-12 months later.
RESULTS: Residual urea clearance was lower (0.7 +/- 1.1 vs. 2.2 +/- 2.4 ml/min; p = 0.034) while systolic blood pressure (162 +/- 21 vs. 147 +/- 11 mm Hg; p = 0.003), duration of dialysis dependence (38 +/- 37 vs. 17 +/- 13 months; p = 0.004) and interdialytic weight gain (1.98 + 0.84 vs. 1.32 + 1.08 kg; p = 0.026) were higher in those with LVH. Parathyroid hormone changed less in those whose LVH regressed (186 +/- 89 vs. 303 +/- 280 pg/ml; p = 0.032). Regression did not occur when parathyroid hormone was >300 pg/ml. ACE gene polymorphism did not affect LVH development or progression.
CONCLUSION: Systolic hypertension, duration of dialysis dependence and high interdialytic weight gains promote LVH. Hyperparathyroidism retards LVH regression.
Original language | English |
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Pages (from-to) | 163-9 |
Number of pages | 7 |
Journal | Blood Purification |
Volume | 21 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Hyperparathyroidism
- Hypertension
- Hypertrophy, Left Ventricular
- Kidney Failure, Chronic
- Male
- Middle Aged
- Parathyroid Hormone
- Peptidyl-Dipeptidase A
- Polymorphism, Genetic
- Renal Dialysis
- Risk Factors
- Ultrasonography
- Weight Gain
- Journal Article