Differential-effects of Nifedipine on nerve-mediated and noradrenaline-evoked contractions of rat anococcygeus muscle

Mahmoud M. Iravani; M. A. Zar

doi:10.1016/0014-2999(93)90643-V

Differential-effects of Nifedipine on nerve-mediated and noradrenaline-evoked contractions of rat anococcygeus muscle

Mahmoud M. Iravani, M. A. Zar

Research output: Contribution to journal › Comment/debate › peer-review

4 Citations (Scopus)

Abstract

In rat anococcygeus muscle the inhibitory effect of nifedipine (0.01. 0.1, 1.0 and 10 muM) was determined on adrenergic twitches in response to electrical field stimulation (trains of 4 pulses, 0.1 ms pulse duration. 10 Hz) and on twitch-matching contractions evoked by noradrenaline. Nifedipine concentration-dependently reduced the neurogenic twitch with an IC50 of 0.083 muM. Nifedipine reduced the noradrenaline-evoked contraction to a markedly lesser degree (IC50 > 10 muM). The difference in the magnitude of inhibition of electrically evoked twitch and twitch-matching noradrenaline-evoked contraction was statistically significant at every concentration of nifedipine. It is concluded that inhibition of the twitch by nifedipine involves some other mechanism(s) in addition to its Ca2+ Channel blocking property in smooth muscle.

Original language	English
Pages (from-to)	193-195
Number of pages	3
Journal	European Journal of Pharmacology
Volume	250
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(93)90643-V
Publication status	Published - 30 Nov 1993

Keywords

ANOCOCCYGEUS MUSCLE
NIFEDIPINE
ADRENERGIC TRANSMISSION
CA2+ CHANNEL ANTAGONIST
NEUROPEPTIDE-Y

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10.1016/0014-2999(93)90643-V

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title = "Differential-effects of Nifedipine on nerve-mediated and noradrenaline-evoked contractions of rat anococcygeus muscle",

abstract = "In rat anococcygeus muscle the inhibitory effect of nifedipine (0.01. 0.1, 1.0 and 10 muM) was determined on adrenergic twitches in response to electrical field stimulation (trains of 4 pulses, 0.1 ms pulse duration. 10 Hz) and on twitch-matching contractions evoked by noradrenaline. Nifedipine concentration-dependently reduced the neurogenic twitch with an IC50 of 0.083 muM. Nifedipine reduced the noradrenaline-evoked contraction to a markedly lesser degree (IC50 > 10 muM). The difference in the magnitude of inhibition of electrically evoked twitch and twitch-matching noradrenaline-evoked contraction was statistically significant at every concentration of nifedipine. It is concluded that inhibition of the twitch by nifedipine involves some other mechanism(s) in addition to its Ca2+ Channel blocking property in smooth muscle.",

keywords = "ANOCOCCYGEUS MUSCLE, NIFEDIPINE, ADRENERGIC TRANSMISSION, CA2+ CHANNEL ANTAGONIST, NEUROPEPTIDE-Y",

author = "Iravani, {Mahmoud M.} and Zar, {M. A.}",

year = "1993",

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doi = "10.1016/0014-2999(93)90643-V",

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T1 - Differential-effects of Nifedipine on nerve-mediated and noradrenaline-evoked contractions of rat anococcygeus muscle

AU - Iravani, Mahmoud M.

AU - Zar, M. A.

PY - 1993/11/30

Y1 - 1993/11/30

N2 - In rat anococcygeus muscle the inhibitory effect of nifedipine (0.01. 0.1, 1.0 and 10 muM) was determined on adrenergic twitches in response to electrical field stimulation (trains of 4 pulses, 0.1 ms pulse duration. 10 Hz) and on twitch-matching contractions evoked by noradrenaline. Nifedipine concentration-dependently reduced the neurogenic twitch with an IC50 of 0.083 muM. Nifedipine reduced the noradrenaline-evoked contraction to a markedly lesser degree (IC50 > 10 muM). The difference in the magnitude of inhibition of electrically evoked twitch and twitch-matching noradrenaline-evoked contraction was statistically significant at every concentration of nifedipine. It is concluded that inhibition of the twitch by nifedipine involves some other mechanism(s) in addition to its Ca2+ Channel blocking property in smooth muscle.

AB - In rat anococcygeus muscle the inhibitory effect of nifedipine (0.01. 0.1, 1.0 and 10 muM) was determined on adrenergic twitches in response to electrical field stimulation (trains of 4 pulses, 0.1 ms pulse duration. 10 Hz) and on twitch-matching contractions evoked by noradrenaline. Nifedipine concentration-dependently reduced the neurogenic twitch with an IC50 of 0.083 muM. Nifedipine reduced the noradrenaline-evoked contraction to a markedly lesser degree (IC50 > 10 muM). The difference in the magnitude of inhibition of electrically evoked twitch and twitch-matching noradrenaline-evoked contraction was statistically significant at every concentration of nifedipine. It is concluded that inhibition of the twitch by nifedipine involves some other mechanism(s) in addition to its Ca2+ Channel blocking property in smooth muscle.

KW - ANOCOCCYGEUS MUSCLE

KW - NIFEDIPINE

KW - ADRENERGIC TRANSMISSION

KW - CA2+ CHANNEL ANTAGONIST

KW - NEUROPEPTIDE-Y

U2 - 10.1016/0014-2999(93)90643-V

DO - 10.1016/0014-2999(93)90643-V

M3 - Comment/debate

SN - 0014-2999

VL - 250

SP - 193

EP - 195

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Differential-effects of Nifedipine on nerve-mediated and noradrenaline-evoked contractions of rat anococcygeus muscle

Abstract

Keywords

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