Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

Paul Facer, Maria A Casula, Graham D Smith, Christopher D Benham, Iain P Chessell, Chas Bountra, Marco Sinisi, Rolfe Birch, Praveen Anand

    Research output: Contribution to journalArticlepeer-review

    222 Citations (Scopus)
    48 Downloads (Pure)

    Abstract

    Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology. We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG. Related receptors TRPV4, activated by warmth and eicosanoids, and TRPM8, activated by cool and menthol, have been characterised in pre-clinical models. However, the role of TRPs in common clinical sensory neuropathies needs to be established.
    Original languageEnglish
    Pages (from-to)11
    JournalBMC Neurology
    Volume7
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Axons
    • Cells, Cultured
    • Diabetic Neuropathies
    • Gene Expression Regulation
    • Humans
    • Peripheral Nerve Injuries
    • Peripheral Nerves
    • Reference Values
    • TRPM Cation Channels
    • TRPV Cation Channels

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