Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

Paul Facer; Maria A Casula; Graham D Smith; Christopher D Benham; Iain P Chessell; Chas Bountra; Marco Sinisi; Rolfe Birch; Praveen Anand

doi:10.1186/1471-2377-7-11

Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

Paul Facer, Maria A Casula, Graham D Smith, Christopher D Benham, Iain P Chessell, Chas Bountra, Marco Sinisi, Rolfe Birch, Praveen Anand

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Abstract

Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology. We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG. Related receptors TRPV4, activated by warmth and eicosanoids, and TRPM8, activated by cool and menthol, have been characterised in pre-clinical models. However, the role of TRPs in common clinical sensory neuropathies needs to be established.

Original language	English
Pages (from-to)	11
Journal	BMC Neurology
Volume	7
DOIs	https://doi.org/10.1186/1471-2377-7-11
Publication status	Published - 2007

Keywords

Axons
Cells, Cultured
Diabetic Neuropathies
Gene Expression Regulation
Humans
Peripheral Nerve Injuries
Peripheral Nerves
Reference Values
TRPM Cation Channels
TRPV Cation Channels

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10.1186/1471-2377-7-11

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© 2007 Facer et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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title = "Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy",

abstract = "Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology. We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG. Related receptors TRPV4, activated by warmth and eicosanoids, and TRPM8, activated by cool and menthol, have been characterised in pre-clinical models. However, the role of TRPs in common clinical sensory neuropathies needs to be established.",

keywords = "Axons, Cells, Cultured, Diabetic Neuropathies, Gene Expression Regulation, Humans, Peripheral Nerve Injuries, Peripheral Nerves, Reference Values, TRPM Cation Channels, TRPV Cation Channels",

author = "Paul Facer and Casula, {Maria A} and Smith, {Graham D} and Benham, {Christopher D} and Chessell, {Iain P} and Chas Bountra and Marco Sinisi and Rolfe Birch and Praveen Anand",

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journal = "BMC Neurology",

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T1 - Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

AU - Facer, Paul

AU - Casula, Maria A

AU - Smith, Graham D

AU - Benham, Christopher D

AU - Chessell, Iain P

AU - Bountra, Chas

AU - Sinisi, Marco

AU - Birch, Rolfe

AU - Anand, Praveen

PY - 2007

Y1 - 2007

N2 - Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology. We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG. Related receptors TRPV4, activated by warmth and eicosanoids, and TRPM8, activated by cool and menthol, have been characterised in pre-clinical models. However, the role of TRPs in common clinical sensory neuropathies needs to be established.

AB - Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology. We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG. Related receptors TRPV4, activated by warmth and eicosanoids, and TRPM8, activated by cool and menthol, have been characterised in pre-clinical models. However, the role of TRPs in common clinical sensory neuropathies needs to be established.

KW - Axons

KW - Cells, Cultured

KW - Diabetic Neuropathies

KW - Gene Expression Regulation

KW - Humans

KW - Peripheral Nerve Injuries

KW - Peripheral Nerves

KW - Reference Values

KW - TRPM Cation Channels

KW - TRPV Cation Channels

U2 - 10.1186/1471-2377-7-11

DO - 10.1186/1471-2377-7-11

M3 - Article

C2 - 17521436

VL - 7

SP - 11

JO - BMC Neurology

JF - BMC Neurology

ER -

Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

Abstract

Keywords

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