Dissection of the contributions toward dimerization of glycopeptide antibiotics

J.P. Mackay, U. Gerhard, D.A. Beauregard, R.A. Maplestone, D.H. Williams

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    133 Citations (Scopus)

    Abstract

    A procedure for the determination of association constants in aqueous solution using hydrogen-deuterium exchange has been developed and used to measure the dimerization constant, K(dim), for a number of strongly dimerizing glycopeptide antibiotics. These values provide further insight into the thermodynamic contributions of various structural epitopes to the dimerization of these antibiotics. Consideration of ligand binding affinities together with dimerization potentials provides evidence that dimerization is implicated in the physiological mode of action of these antibiotics.
    Original languageEnglish
    Pages (from-to)4573-4580
    Number of pages8
    JournalJournal of the American Chemical Society
    Volume116
    Issue number11
    DOIs
    Publication statusPublished - 1 Jun 1994

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