Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

Andrei I Tarasov, Patrik Rorsman

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.

Original languageEnglish
Pages (from-to)8-10
Number of pages3
JournalCell metabolism
Issue number1
Publication statusPublished - 12 Jan 2016


  • Diabetes Mellitus, Type 2
  • Humans
  • Insulin
  • Insulin Resistance
  • Insulin-Secreting Cells
  • Liver


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