Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

Andrei I Tarasov; Patrik Rorsman

doi:10.1016/j.cmet.2015.12.011

Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

Andrei I Tarasov
, Patrik Rorsman

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.

Original language	English
Pages (from-to)	8-10
Number of pages	3
Journal	Cell metabolism
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2015.12.011
Publication status	Published - 12 Jan 2016

Keywords

Diabetes Mellitus, Type 2
Humans
Insulin
Insulin Resistance
Insulin-Secreting Cells
Liver

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abstract = "How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.",

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AU - Rorsman, Patrik

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KW - Diabetes Mellitus, Type 2

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Insulin-Secreting Cells

KW - Liver

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DO - 10.1016/j.cmet.2015.12.011

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Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

Abstract

Keywords

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