Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease

D. D. Ateh; I. K. Hussain; A. H. Mustafa; K. M. Price; R. Gulati; C. D. Nickols; M. M. Bird; L. Greensmith; M. Hafezparast; E. M. C. Fisher; C. S. Baker; J. E. Martin

doi:10.1111/j.1365-2990.2007.00924.x

Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease

D. D. Ateh, I. K. Hussain, A. H. Mustafa, K. M. Price, R. Gulati, C. D. Nickols, M. M. Bird, L. Greensmith, M. Hafezparast, E. M. C. Fisher, C. S. Baker, J. E. Martin

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The dynein-dynactin complex, mostly recognized for axonal retrograde transport in neurones, has an ever growing list of essential subcellular functions. Here, the distribution of complex subunits in human central nervous system (CNS) has been assessed using immunohistochemistry in order to test the hypothesis that this may be altered in neurodegenerative disease.

Original language	English
Pages (from-to)	88-94
Number of pages	7
Journal	Neuropathology and Applied Neurobiology
Volume	34
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2990.2007.00924.x
Publication status	Published - Feb 2008

Keywords

Spinal Cord
Microtubule-Associated Proteins
Neurons
Inclusion Bodies
Humans
Brain
Neurodegenerative Diseases
Neurofibrillary Tangles
Immunohistochemistry
Dyneins

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10.1111/j.1365-2990.2007.00924.x

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Ateh, D. D., Hussain, I. K., Mustafa, A. H., Price, K. M., Gulati, R., Nickols, C. D., Bird, M. M., Greensmith, L., Hafezparast, M., Fisher, E. M. C., Baker, C. S., & Martin, J. E. (2008). Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease. Neuropathology and Applied Neurobiology, 34(1), 88-94. https://doi.org/10.1111/j.1365-2990.2007.00924.x

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title = "Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease",

abstract = "The dynein-dynactin complex, mostly recognized for axonal retrograde transport in neurones, has an ever growing list of essential subcellular functions. Here, the distribution of complex subunits in human central nervous system (CNS) has been assessed using immunohistochemistry in order to test the hypothesis that this may be altered in neurodegenerative disease.",

keywords = "Spinal Cord, Microtubule-Associated Proteins, Neurons, Inclusion Bodies, Humans, Brain, Neurodegenerative Diseases, Neurofibrillary Tangles, Immunohistochemistry, Dyneins",

author = "Ateh, {D. D.} and Hussain, {I. K.} and Mustafa, {A. H.} and Price, {K. M.} and R. Gulati and Nickols, {C. D.} and Bird, {M. M.} and L. Greensmith and M. Hafezparast and Fisher, {E. M. C.} and Baker, {C. S.} and Martin, {J. E.}",

year = "2008",

month = feb,

doi = "10.1111/j.1365-2990.2007.00924.x",

language = "English",

volume = "34",

pages = "88--94",

journal = "Neuropathology and Applied Neurobiology",

issn = "0305-1846",

publisher = "Wiley-Blackwell",

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}

Ateh, DD, Hussain, IK, Mustafa, AH, Price, KM, Gulati, R, Nickols, CD, Bird, MM, Greensmith, L, Hafezparast, M, Fisher, EMC, Baker, CS & Martin, JE 2008, 'Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease', Neuropathology and Applied Neurobiology, vol. 34, no. 1, pp. 88-94. https://doi.org/10.1111/j.1365-2990.2007.00924.x

Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease. / Ateh, D. D.; Hussain, I. K.; Mustafa, A. H. et al.
In: Neuropathology and Applied Neurobiology, Vol. 34, No. 1, 02.2008, p. 88-94.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease

AU - Ateh, D. D.

AU - Hussain, I. K.

AU - Mustafa, A. H.

AU - Price, K. M.

AU - Gulati, R.

AU - Nickols, C. D.

AU - Bird, M. M.

AU - Greensmith, L.

AU - Hafezparast, M.

AU - Fisher, E. M. C.

AU - Baker, C. S.

AU - Martin, J. E.

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AB - The dynein-dynactin complex, mostly recognized for axonal retrograde transport in neurones, has an ever growing list of essential subcellular functions. Here, the distribution of complex subunits in human central nervous system (CNS) has been assessed using immunohistochemistry in order to test the hypothesis that this may be altered in neurodegenerative disease.

KW - Spinal Cord

KW - Microtubule-Associated Proteins

KW - Neurons

KW - Inclusion Bodies

KW - Humans

KW - Brain

KW - Neurodegenerative Diseases

KW - Neurofibrillary Tangles

KW - Immunohistochemistry

KW - Dyneins

U2 - 10.1111/j.1365-2990.2007.00924.x

DO - 10.1111/j.1365-2990.2007.00924.x

M3 - Article

C2 - 18086204

SN - 0305-1846

VL - 34

SP - 88

EP - 94

JO - Neuropathology and Applied Neurobiology

JF - Neuropathology and Applied Neurobiology

IS - 1

ER -

Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease

Abstract

Keywords

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