Effect of molecular weight and concentration hyaluronan on the in-vitro release characteristics of ibuprofen and diclofenac sodium across cellulose membrane

W. J. He, Marc Brown, Gary P. Martin

Research output: Contribution to journalMeeting abstractpeer-review

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Abstract

Hyaluronan (HA) is a naturally occurring polyanionic glycosaminoglycan.
Drugs formulated in HA and applied topically are retained in the skin with
little systemic absorption (Brown et al 2000, 2001). However, the precise
mechanism of action of HA that facilitates drug delivery and promotes drug
localization remain unclear. In this study we investigated the in-vitro release
characteristics of two NSAID drugs, ibuprofen (IBF) and diclofenac sodium
(DFS), incorporated into vehicles containing four different molecular weight
(MW) grades and different concentrations of HA across cellulose membrane
Original languageEnglish
Pages (from-to)13
Number of pages1
JournalJournal of Pharmacy and Pharmacology
Volume56
Issue numberS1
DOIs
Publication statusPublished - Sep 2004

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