Effect of oral 1,25 dihydroxycholecalciferol on calcium and phosphate malabsorption in primary biliary cirrhosis

K. Farrington; O. Epstein; Z. Varghese; S. P. Newman; J. F. Moorhead; S. Sherlock

doi:10.1136/gut.20.7.616

Effect of oral 1,25 dihydroxycholecalciferol on calcium and phosphate malabsorption in primary biliary cirrhosis

K. Farrington, O. Epstein, Z. Varghese, S. P. Newman, J. F. Moorhead, S. Sherlock

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4 Citations (Scopus)

Abstract

Changes in calcium and phosphate absorption in response to treatment with small doses of oral 1,25 (OH)2D3 were studied in 10 patients with primary biliary cirrhosis by means of a combined radio-isotope technique. There was a marked improvement in the fractional rates of absorption of calcium (p < 0.01) and phosphate (0.05 < p < 0.1) after treatment. This implies that there is no end organ unresponsiveness to the action of active Vitamin D metabolites at the intestinal level in primary biliary cirrhosis.

Original language	English
Pages (from-to)	616-619
Number of pages	4
Journal	Gut
Volume	20
Issue number	7
DOIs	https://doi.org/10.1136/gut.20.7.616
Publication status	Published - Jul 1979

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abstract = "Changes in calcium and phosphate absorption in response to treatment with small doses of oral 1,25 (OH)2D3 were studied in 10 patients with primary biliary cirrhosis by means of a combined radio-isotope technique. There was a marked improvement in the fractional rates of absorption of calcium (p < 0.01) and phosphate (0.05 < p < 0.1) after treatment. This implies that there is no end organ unresponsiveness to the action of active Vitamin D metabolites at the intestinal level in primary biliary cirrhosis.",

author = "K. Farrington and O. Epstein and Z. Varghese and Newman, {S. P.} and Moorhead, {J. F.} and S. Sherlock",

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AU - Farrington, K.

AU - Epstein, O.

AU - Varghese, Z.

AU - Newman, S. P.

AU - Moorhead, J. F.

AU - Sherlock, S.

PY - 1979/7

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N2 - Changes in calcium and phosphate absorption in response to treatment with small doses of oral 1,25 (OH)2D3 were studied in 10 patients with primary biliary cirrhosis by means of a combined radio-isotope technique. There was a marked improvement in the fractional rates of absorption of calcium (p < 0.01) and phosphate (0.05 < p < 0.1) after treatment. This implies that there is no end organ unresponsiveness to the action of active Vitamin D metabolites at the intestinal level in primary biliary cirrhosis.

AB - Changes in calcium and phosphate absorption in response to treatment with small doses of oral 1,25 (OH)2D3 were studied in 10 patients with primary biliary cirrhosis by means of a combined radio-isotope technique. There was a marked improvement in the fractional rates of absorption of calcium (p < 0.01) and phosphate (0.05 < p < 0.1) after treatment. This implies that there is no end organ unresponsiveness to the action of active Vitamin D metabolites at the intestinal level in primary biliary cirrhosis.

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Effect of oral 1,25 dihydroxycholecalciferol on calcium and phosphate malabsorption in primary biliary cirrhosis

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