Abstract
For saturated formulations, where thermodynamic activity () is equal
to 1, the flux of the permeant through a membrane should theoretically be constant
irrespective of the delivery vehicle (Higuchi 1960). Although some studies have
supported this hypothesis for saturated binary mixtures of propylene glycol (PG)/
water (e.g. Twist and Zatz 1986), variations from this ideal behaviour have been
reported (e.g. Pellett et al 1994). Therefore, no definitive conclusions have been
made regarding the influence of PG on the membrane transport rate of drugs from
saturated vehicles. The aim of this study was to investigate systematically the
impact of PG on the permeation of one drug, diclofenac diethylamine (DDEA),
from a series of saturated binary mixtures, through model membranes.
to 1, the flux of the permeant through a membrane should theoretically be constant
irrespective of the delivery vehicle (Higuchi 1960). Although some studies have
supported this hypothesis for saturated binary mixtures of propylene glycol (PG)/
water (e.g. Twist and Zatz 1986), variations from this ideal behaviour have been
reported (e.g. Pellett et al 1994). Therefore, no definitive conclusions have been
made regarding the influence of PG on the membrane transport rate of drugs from
saturated vehicles. The aim of this study was to investigate systematically the
impact of PG on the permeation of one drug, diclofenac diethylamine (DDEA),
from a series of saturated binary mixtures, through model membranes.
| Original language | English |
|---|---|
| Pages (from-to) | A57 |
| Number of pages | 1 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 60 |
| Issue number | Supp 1 |
| DOIs | |
| Publication status | Published - Sept 2008 |