Effects of nano CuO on hippocampal neurons and differentiated PC12 cells

L. Xu, J. Zhao, S. Liu, T. Zhang, Guogang Ren, Z. Yang

Research output: Contribution to journalArticlepeer-review


The effects of nanoparticles of CuO on delayed rectifier potassium current (Ik) were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus by using the whole-cell patch-clamp techniques and the effects on differentiated PC12 cell viability were studied with MTT assay. Nanoparticles of CuO mainly inhibited Ik in the concentration of 5×10-5 g/mL. Nanoparticles of CuO didn't shift the steady-state activation curve of Ik but negatively shift the inactivation curve of Ik. Nanoparticles of CuO (5×10-4, 5×10-5 and 5×10-6 g/mL) induced differentiated PC12 cells damage with dose-and time-dependent manner.
Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalActa Biophysica Sinica
Issue number2
Publication statusPublished - 2008


  • nanomaterial
  • delayed rectifier potassium
  • hippocampal neurons
  • PC12
  • biological effects


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