Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model

Simon D. Baines; Jane Freeman; Mark H. Wilcox

doi:10.1093/jac/dki120

Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model

Simon D. Baines, Jane Freeman, Mark H. Wilcox

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77 Citations (Scopus)

Abstract

Clostridium difficile infection (CDI) is a major cause of morbidity in the nosocomial environment. Antimicrobial agents such as the third-generation cephalosporins, lincosamides and aminopenicillins are well known for their propensity to induce CDI, but the definitive reasons why remain to be elucidated. Despite their broad spectrum of activity against both aerobic and anaerobic bacteria, the ureidopenicillins remain a class of antimicrobials infrequently associated with the development of CDI.

Original language	English
Pages (from-to)	974-82
Number of pages	9
Journal	Journal of Antimicrobial Chemotherapy
Volume	55
Issue number	6
DOIs	https://doi.org/10.1093/jac/dki120
Publication status	Published - Jun 2005

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10.1093/jac/dki120

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title = "Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model",

abstract = "Clostridium difficile infection (CDI) is a major cause of morbidity in the nosocomial environment. Antimicrobial agents such as the third-generation cephalosporins, lincosamides and aminopenicillins are well known for their propensity to induce CDI, but the definitive reasons why remain to be elucidated. Despite their broad spectrum of activity against both aerobic and anaerobic bacteria, the ureidopenicillins remain a class of antimicrobials infrequently associated with the development of CDI.",

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AU - Freeman, Jane

AU - Wilcox, Mark H.

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AB - Clostridium difficile infection (CDI) is a major cause of morbidity in the nosocomial environment. Antimicrobial agents such as the third-generation cephalosporins, lincosamides and aminopenicillins are well known for their propensity to induce CDI, but the definitive reasons why remain to be elucidated. Despite their broad spectrum of activity against both aerobic and anaerobic bacteria, the ureidopenicillins remain a class of antimicrobials infrequently associated with the development of CDI.

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DO - 10.1093/jac/dki120

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

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ER -

Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model

Abstract

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