TY - JOUR
T1 - Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications
T2 - Circumstantial Insight on Mechanistic Aspects
AU - Khan, Maarij
AU - Mashwani, Zia-Ur-Rehman
AU - Ikram, Muhammad
AU - Raja, Naveed I
AU - Mohamed, Azza H
AU - Ren, Guogang
AU - Omar, Ahmad A
N1 - © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
PY - 2022/6/20
Y1 - 2022/6/20
N2 - Green synthesized cerium oxide nanoparticles (GS-CeO 2 NPs) have a unique size, shape, and biofunctional properties and are decorated with potential biocompatible agents to perform various therapeutic actions, such as antimicrobial, anticancer, antidiabetic, and antioxidant effects and drug delivery, by acquiring various mechanistic approaches at the molecular level. In this review article, we provide a detailed overview of some of these critical mechanisms, including DNA fragmentation, disruption of the electron transport chain, degradation of chromosomal assemblage, mitochondrial damage, inhibition of ATP synthase activity, inhibition of enzyme catalytic sites, disorganization, disruption, and lipid peroxidation of the cell membrane, and inhibition of various cellular pathways. This review article also provides up-to-date information about the future applications of GS-CeONPs to make breakthroughs in medical sectors for the advancement and precision of medicine and to effectively inform the disease diagnosis and treatment strategies.
AB - Green synthesized cerium oxide nanoparticles (GS-CeO 2 NPs) have a unique size, shape, and biofunctional properties and are decorated with potential biocompatible agents to perform various therapeutic actions, such as antimicrobial, anticancer, antidiabetic, and antioxidant effects and drug delivery, by acquiring various mechanistic approaches at the molecular level. In this review article, we provide a detailed overview of some of these critical mechanisms, including DNA fragmentation, disruption of the electron transport chain, degradation of chromosomal assemblage, mitochondrial damage, inhibition of ATP synthase activity, inhibition of enzyme catalytic sites, disorganization, disruption, and lipid peroxidation of the cell membrane, and inhibition of various cellular pathways. This review article also provides up-to-date information about the future applications of GS-CeONPs to make breakthroughs in medical sectors for the advancement and precision of medicine and to effectively inform the disease diagnosis and treatment strategies.
KW - DNA fragmentation
KW - antimicrobial
KW - cancer
KW - cerium metal
KW - diabetes
KW - drug delivery
KW - lipid peroxidation
UR - http://www.scopus.com/inward/record.url?scp=85132132046&partnerID=8YFLogxK
U2 - 10.3390/nano12122117
DO - 10.3390/nano12122117
M3 - Review article
C2 - 35745455
SN - 2079-4991
VL - 12
JO - Nanomaterials
JF - Nanomaterials
IS - 12
M1 - 2117
ER -