Efficacy of Green Cerium Oxide Nanoparticles for Potential Therapeutic Applications: Circumstantial Insight on Mechanistic Aspects

Maarij Khan, Zia-Ur-Rehman Mashwani, Muhammad Ikram, Naveed I Raja, Azza H Mohamed, Guogang Ren, Ahmad A Omar

Research output: Contribution to journalReview articlepeer-review

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Abstract

Green synthesized cerium oxide nanoparticles (GS-CeO 2 NPs) have a unique size, shape, and biofunctional properties and are decorated with potential biocompatible agents to perform various therapeutic actions, such as antimicrobial, anticancer, antidiabetic, and antioxidant effects and drug delivery, by acquiring various mechanistic approaches at the molecular level. In this review article, we provide a detailed overview of some of these critical mechanisms, including DNA fragmentation, disruption of the electron transport chain, degradation of chromosomal assemblage, mitochondrial damage, inhibition of ATP synthase activity, inhibition of enzyme catalytic sites, disorganization, disruption, and lipid peroxidation of the cell membrane, and inhibition of various cellular pathways. This review article also provides up-to-date information about the future applications of GS-CeONPs to make breakthroughs in medical sectors for the advancement and precision of medicine and to effectively inform the disease diagnosis and treatment strategies.

Original languageEnglish
Article number2117
JournalNanomaterials
Volume12
Issue number12
DOIs
Publication statusPublished - 20 Jun 2022

Keywords

  • DNA fragmentation
  • antimicrobial
  • cancer
  • cerium metal
  • diabetes
  • drug delivery
  • lipid peroxidation

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