Emergence of reduced susceptibility to metronidazole in Clostridium difficile

Simon D. Baines; Rachael O'Connor; Jane Freeman; Warren N Fawley; Celine Harmanus; Paola Mastrantonio; Ed J. Kuijper; M. H. Wilcox

doi:10.1093/jac/dkn313

Emergence of reduced susceptibility to metronidazole in Clostridium difficile

Simon D. Baines
, Rachael O'Connor
, Jane Freeman
, Warren N Fawley
, Celine Harmanus
, Paola Mastrantonio
, Ed J. Kuijper
, M. H. Wilcox

Research output: Contribution to journal › Article › peer-review

214 Citations (Scopus)

Abstract

Antimicrobial treatment for Clostridium difficile infection (CDI) has typically been metronidazole, although reports have questioned the efficacy of this option. We screened recently isolated C. difficile (2005-06) for susceptibility to metronidazole and compared results for historic isolates (1995-2001).

Original language	English
Pages (from-to)	1046-52
Number of pages	7
Journal	Journal of Antimicrobial Chemotherapy
Volume	62
Issue number	5
DOIs	https://doi.org/10.1093/jac/dkn313
Publication status	Published - 2008

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title = "Emergence of reduced susceptibility to metronidazole in Clostridium difficile",

abstract = "Antimicrobial treatment for Clostridium difficile infection (CDI) has typically been metronidazole, although reports have questioned the efficacy of this option. We screened recently isolated C. difficile (2005-06) for susceptibility to metronidazole and compared results for historic isolates (1995-2001).",

author = "Baines, \{Simon D.\} and Rachael O'Connor and Jane Freeman and Fawley, \{Warren N\} and Celine Harmanus and Paola Mastrantonio and Kuijper, \{Ed J.\} and Wilcox, \{M. H.\}",

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T1 - Emergence of reduced susceptibility to metronidazole in Clostridium difficile

AU - Baines, Simon D.

AU - O'Connor, Rachael

AU - Freeman, Jane

AU - Fawley, Warren N

AU - Harmanus, Celine

AU - Mastrantonio, Paola

AU - Kuijper, Ed J.

AU - Wilcox, M. H.

PY - 2008

Y1 - 2008

N2 - Antimicrobial treatment for Clostridium difficile infection (CDI) has typically been metronidazole, although reports have questioned the efficacy of this option. We screened recently isolated C. difficile (2005-06) for susceptibility to metronidazole and compared results for historic isolates (1995-2001).

AB - Antimicrobial treatment for Clostridium difficile infection (CDI) has typically been metronidazole, although reports have questioned the efficacy of this option. We screened recently isolated C. difficile (2005-06) for susceptibility to metronidazole and compared results for historic isolates (1995-2001).

U2 - 10.1093/jac/dkn313

DO - 10.1093/jac/dkn313

M3 - Article

C2 - 18693234

SN - 1460-2091

VL - 62

SP - 1046

EP - 1052

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 5

ER -

Emergence of reduced susceptibility to metronidazole in Clostridium difficile

Abstract

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