Emotion dysregulation, impulsivity and anger rumination in borderline personality disorder: the role of amygdala and insula

M. Mitolo, F. D’Adda, S. Evangelisti, L. Pellegrini, L. L. Gramegna, C. Bianchini, L. Talozzi, D. N. Manners, C. Testa, D. Berardi, R. Lodi, M. Menchetti, C. Tonon

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Abstract

Borderline Personality Disorder (BPD) is a severe mental disorder, characterized by deficits in emotion regulation, interpersonal dysfunctions, dissociation and impulsivity. Brain abnormalities have been generally explored; however, the specific contribution of different limbic structures to BPD symptomatology is not described. The aim of this study is to cover this gap, exploring functional and structural alterations of amygdala and insula and to highlight their contribution to neuropsychiatric symptoms. Twenty-eight BPD patients (23.7 ± 3.42 years; 6 M/22F) and twenty-eight matched healthy controls underwent a brain MR protocol (1.5 T, including a 3D T1-weighted sequence and resting-state fMRI) and a complete neuropsychiatric assessment. Volumetry, cortical thickness and functional connectivity of amygdala and insula were evaluated, along with correlations with the neuropsychiatric scales. BPD patients showed a lower cortical thickness of the left insula (p = 0.027) that negatively correlated with the Anger Rumination Scale (p = 0.019; r = − 0.450). A focused analysis on female patients showed a significant reduction of right amygdala volumes in BPD (p = 0.037), that correlate with Difficulties in Emotion Regulation Scale (p = 0.031; r = − 0.415), Beck Depression Inventory (p = 0.009; r = − 0.50) and Ruminative Response Scale (p = 0.045; r = − 0.389). Reduced functional connectivity was found in BPD between amygdala and frontal pole, precuneus and temporal pole. This functional connectivity alterations correlated with Anger Rumination Scale (p = .009; r = − 0.491) and Barratt Impulsiveness Scale (p = 0.020; r = − 0.447). Amygdala and insula are altered in BPD patients, and these two limbic structures are implicated in specific neuropsychiatric symptoms, such as difficulty in emotion regulation, depression, anger and depressive rumination.
Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume274
Issue number1
Early online date22 Apr 2023
DOIs
Publication statusE-pub ahead of print - 22 Apr 2023

Keywords

  • Emotion dysregulation
  • Amygdala
  • Impulsivity
  • Borderline personality disorder
  • Insula
  • Anger rumination

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