Eta(1)-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): a delicate balance between stability and CO liberation

Ian J S Fairlamb; Jason M Lynam; Benjamin E Moulton; Ian E Taylor; Anne K Duhme-Klair; Philip Sawle; Roberto Motterlini

doi:10.1039/b707377a

Eta(1)-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): a delicate balance between stability and CO liberation

Ian J S Fairlamb
, Jason M Lynam
, Benjamin E Moulton
, Ian E Taylor
, Anne K Duhme-Klair
, Philip Sawle
, Roberto Motterlini

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

An evaluation of the CO releasing ability of iron(II) and molybdenum(II) complexes has facilitated the discovery of the most rapid CO releaser, namely [Mo(CO)(3)(eta(5)-C(5)H(5))(eta(1)-{O}-C{=O}-O-CMe=CH-COMe=CBr)]BF(4) (CORM-F10), reported to date. The rate of CO release is related to the overall solution phase stability of the transition metal carbonyl complex. The cytotoxicity and vasodilatory properties of CORM-F10 have been determined.

Original language	English
Pages (from-to)	3603-5
Number of pages	3
Journal	Dalton Transactions
Issue number	33
DOIs	https://doi.org/10.1039/b707377a
Publication status	Published - 7 Sept 2007

Keywords

Animals
Aorta
Carbon Monoxide
Drug Stability
Iron
Molecular Structure
Molybdenum
Organometallic Compounds
Pyrones
Vasodilator Agents
Journal Article
Research Support, Non-U.S. Gov't

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title = "Eta(1)-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): a delicate balance between stability and CO liberation",

abstract = "An evaluation of the CO releasing ability of iron(II) and molybdenum(II) complexes has facilitated the discovery of the most rapid CO releaser, namely [Mo(CO)(3)(eta(5)-C(5)H(5))(eta(1)-\{O\}-C\{=O\}-O-CMe=CH-COMe=CBr)]BF(4) (CORM-F10), reported to date. The rate of CO release is related to the overall solution phase stability of the transition metal carbonyl complex. The cytotoxicity and vasodilatory properties of CORM-F10 have been determined.",

keywords = "Animals, Aorta, Carbon Monoxide, Drug Stability, Iron, Molecular Structure, Molybdenum, Organometallic Compounds, Pyrones, Vasodilator Agents, Journal Article, Research Support, Non-U.S. Gov't",

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year = "2007",

month = sep,

day = "7",

doi = "10.1039/b707377a",

language = "English",

pages = "3603--5",

journal = "Dalton Transactions",

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T1 - Eta(1)-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs)

T2 - a delicate balance between stability and CO liberation

AU - Fairlamb, Ian J S

AU - Lynam, Jason M

AU - Moulton, Benjamin E

AU - Taylor, Ian E

AU - Duhme-Klair, Anne K

AU - Sawle, Philip

AU - Motterlini, Roberto

PY - 2007/9/7

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N2 - An evaluation of the CO releasing ability of iron(II) and molybdenum(II) complexes has facilitated the discovery of the most rapid CO releaser, namely [Mo(CO)(3)(eta(5)-C(5)H(5))(eta(1)-{O}-C{=O}-O-CMe=CH-COMe=CBr)]BF(4) (CORM-F10), reported to date. The rate of CO release is related to the overall solution phase stability of the transition metal carbonyl complex. The cytotoxicity and vasodilatory properties of CORM-F10 have been determined.

AB - An evaluation of the CO releasing ability of iron(II) and molybdenum(II) complexes has facilitated the discovery of the most rapid CO releaser, namely [Mo(CO)(3)(eta(5)-C(5)H(5))(eta(1)-{O}-C{=O}-O-CMe=CH-COMe=CBr)]BF(4) (CORM-F10), reported to date. The rate of CO release is related to the overall solution phase stability of the transition metal carbonyl complex. The cytotoxicity and vasodilatory properties of CORM-F10 have been determined.

KW - Animals

KW - Aorta

KW - Carbon Monoxide

KW - Drug Stability

KW - Iron

KW - Molecular Structure

KW - Molybdenum

KW - Organometallic Compounds

KW - Pyrones

KW - Vasodilator Agents

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1039/b707377a

DO - 10.1039/b707377a

M3 - Article

C2 - 17700821

SN - 1477-9226

SP - 3603

EP - 3605

JO - Dalton Transactions

JF - Dalton Transactions

IS - 33

ER -

Eta(1)-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): a delicate balance between stability and CO liberation

Abstract

Keywords

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