Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

Ian J S Fairlamb, Anne-Kathrin Duhme-Klair, Jason M Lynam, Benjamin E Moulton, Ciara T O'Brien, Philip Sawle, Jehad Hammad, Roberto Motterlini

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61 Citations (Scopus)


The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta4-2-pyrone)Fe(CO)3 complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications.

Original languageEnglish
Pages (from-to)995-8
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Issue number4
Publication statusPublished - 15 Feb 2006


  • Animals
  • Carbon Monoxide
  • Cell Survival
  • Ferric Compounds
  • Iron
  • Ligands
  • Macrophages
  • Mice
  • Molecular Structure
  • Pyrones
  • Time Factors
  • Journal Article
  • Research Support, Non-U.S. Gov't


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