Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

Ian J S Fairlamb; Anne-Kathrin Duhme-Klair; Jason M Lynam; Benjamin E Moulton; Ciara T O'Brien; Philip Sawle; Jehad Hammad; Roberto Motterlini

doi:10.1016/j.bmcl.2005.10.085

Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

Ian J S Fairlamb
, Anne-Kathrin Duhme-Klair
, Jason M Lynam
, Benjamin E Moulton
, Ciara T O'Brien
, Philip Sawle
, Jehad Hammad
, Roberto Motterlini

Department of Clinical, Pharmaceutical and Biological Science

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta4-2-pyrone)Fe(CO)3 complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications.

Original language	English
Pages (from-to)	995-8
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2005.10.085
Publication status	Published - 15 Feb 2006

Keywords

Animals
Carbon Monoxide
Cell Survival
Ferric Compounds
Iron
Ligands
Macrophages
Mice
Molecular Structure
Pyrones
Time Factors
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.bmcl.2005.10.085

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title = "Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)",

abstract = "The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta4-2-pyrone)Fe(CO)3 complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications.",

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doi = "10.1016/j.bmcl.2005.10.085",

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T1 - Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

AU - Fairlamb, Ian J S

AU - Duhme-Klair, Anne-Kathrin

AU - Lynam, Jason M

AU - Moulton, Benjamin E

AU - O'Brien, Ciara T

AU - Sawle, Philip

AU - Hammad, Jehad

AU - Motterlini, Roberto

PY - 2006/2/15

Y1 - 2006/2/15

N2 - The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta4-2-pyrone)Fe(CO)3 complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications.

AB - The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta4-2-pyrone)Fe(CO)3 complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications.

KW - Animals

KW - Carbon Monoxide

KW - Cell Survival

KW - Ferric Compounds

KW - Iron

KW - Ligands

KW - Macrophages

KW - Mice

KW - Molecular Structure

KW - Pyrones

KW - Time Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.bmcl.2005.10.085

DO - 10.1016/j.bmcl.2005.10.085

M3 - Article

C2 - 16289810

SN - 0960-894X

VL - 16

SP - 995

EP - 998

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 4

ER -

Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

Abstract

Keywords

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