Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model

Simon D. Baines; Alan R. Noel; Grace S. Huscroft; Sharie L. Todhunter; Rachael O'Connor; Joanne K. Hobbs; Jane Freeman; Andy M. Lovering; M. H. Wilcox

doi:10.1093/jac/dkr155

Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model

Simon D. Baines
, Alan R. Noel
, Grace S. Huscroft
, Sharie L. Todhunter
, Rachael O'Connor
, Joanne K. Hobbs
, Jane Freeman
, Andy M. Lovering
, M. H. Wilcox

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI.

Original language	English
Pages (from-to)	1537-46
Number of pages	10
Journal	Journal of Antimicrobial Chemotherapy
Volume	66
Issue number	7
DOIs	https://doi.org/10.1093/jac/dkr155
Publication status	Published - 2011

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Baines, S. D., Noel, A. R., Huscroft, G. S., Todhunter, S. L., O'Connor, R., Hobbs, J. K., Freeman, J., Lovering, A. M., & Wilcox, M. H. (2011). Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model. Journal of Antimicrobial Chemotherapy, 66(7), 1537-46. https://doi.org/10.1093/jac/dkr155

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title = "Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model",

abstract = "Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI.",

author = "Baines, \{Simon D.\} and Noel, \{Alan R.\} and Huscroft, \{Grace S.\} and Todhunter, \{Sharie L.\} and Rachael O'Connor and Hobbs, \{Joanne K.\} and Jane Freeman and Lovering, \{Andy M.\} and Wilcox, \{M. H.\}",

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doi = "10.1093/jac/dkr155",

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AU - Baines, Simon D.

AU - Noel, Alan R.

AU - Huscroft, Grace S.

AU - Todhunter, Sharie L.

AU - O'Connor, Rachael

AU - Hobbs, Joanne K.

AU - Freeman, Jane

AU - Lovering, Andy M.

AU - Wilcox, M. H.

PY - 2011

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N2 - Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI.

AB - Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI.

UR - https://www.scopus.com/pages/publications/79958807215

U2 - 10.1093/jac/dkr155

DO - 10.1093/jac/dkr155

M3 - Article

C2 - 21504940

SN - 1460-2091

VL - 66

SP - 1537

EP - 1546

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

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ER -

Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model

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