Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model

Simon D. Baines; Alan R. Noel; Grace S. Huscroft; Sharie L. Todhunter; Rachael O'Connor; Joanne K. Hobbs; Jane Freeman; Andy M. Lovering; M. H. Wilcox

doi:10.1093/jac/dkr155

Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model

Simon D. Baines, Alan R. Noel, Grace S. Huscroft, Sharie L. Todhunter, Rachael O'Connor, Joanne K. Hobbs, Jane Freeman, Andy M. Lovering, M. H. Wilcox

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30 Citations (Scopus)

Abstract

Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI.

Original language	English
Pages (from-to)	1537-46
Number of pages	10
Journal	Journal of Antimicrobial Chemotherapy
Volume	66
Issue number	7
DOIs	https://doi.org/10.1093/jac/dkr155
Publication status	Published - 2011

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Baines, S. D., Noel, A. R., Huscroft, G. S., Todhunter, S. L., O'Connor, R., Hobbs, J. K., Freeman, J., Lovering, A. M., & Wilcox, M. H. (2011). Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model. Journal of Antimicrobial Chemotherapy, 66(7), 1537-46. https://doi.org/10.1093/jac/dkr155

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title = "Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model",

abstract = "Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI.",

author = "Baines, \{Simon D.\} and Noel, \{Alan R.\} and Huscroft, \{Grace S.\} and Todhunter, \{Sharie L.\} and Rachael O'Connor and Hobbs, \{Joanne K.\} and Jane Freeman and Lovering, \{Andy M.\} and Wilcox, \{M. H.\}",

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doi = "10.1093/jac/dkr155",

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AU - Baines, Simon D.

AU - Noel, Alan R.

AU - Huscroft, Grace S.

AU - Todhunter, Sharie L.

AU - O'Connor, Rachael

AU - Hobbs, Joanne K.

AU - Freeman, Jane

AU - Lovering, Andy M.

AU - Wilcox, M. H.

PY - 2011

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N2 - Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI.

AB - Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI.

UR - https://www.scopus.com/pages/publications/79958807215

U2 - 10.1093/jac/dkr155

DO - 10.1093/jac/dkr155

M3 - Article

C2 - 21504940

SN - 1460-2091

VL - 66

SP - 1537

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

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ER -

Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model

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