Keyphrases
Cytochrome P450 Enzymes
100%
Clearance Prediction
100%
In Vitro System
100%
Recombinant
100%
P450
100%
Metabolic Clearance
100%
P450 Enzymes
80%
Human Liver Microsomes
80%
Relative Abundance
40%
In Vivo Clearance
40%
Drug Depletion
40%
Cytochrome P450 1A2 (CYP1A2)
40%
Relative Activity Factor
40%
Hepatocytes
40%
Cytochrome P450 2D6 (CYP2D6)
40%
Cytochrome P450 3A4 (CYP3A4)
40%
CYP2C9
40%
P450s
20%
Simultaneous Determination
20%
Diclofenac
20%
Fraction Unbound
20%
Catalytic Activity
20%
Midazolam
20%
Parallel Tube Model
20%
Reliability Prediction
20%
Activity-based Approach
20%
Relative Activity
20%
Probe Substrate
20%
Assay Sensitivity
20%
Recombinant Enzyme
20%
Drug Metabolites
20%
Cryopreserved
20%
Improved Prediction
20%
Low Bias
20%
Intrinsic Clearance
20%
CYP2C19
20%
Phenacetin
20%
Cytochrome P450 (CYP450)
20%
Metabolite Formation
20%
Non-specific Binding
20%
Depletion Method
20%
Pharmacology, Toxicology and Pharmaceutical Science
Cytochrome P450
100%
CYP3A4
18%
CYP1A2
18%
CYP2D6
18%
CYP2C9
18%
Midazolam
9%
Recombinant Enzyme
9%
Intrinsic Clearance
9%
Diclofenac
9%
Recombinant
9%
Phenacetin
9%
CYP2C19
9%