Evaluation of the ability of a novel miconazole formulation to penetrate nail by using three in vitro nail models

Luisa Christensen, Rob Turner, Sean Weaver, Francesco Caserta, Lisa Long, Mahmoud Ghannoum, Marc Brown

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
46 Downloads (Pure)

Abstract

In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.

Original languageEnglish
Article numbere02554-16
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Miconazole
  • Onychomycosis
  • Topical

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